Prouse Teagan, Majumder Samarpan, Majumder Rinku
Department of Interdisciplinary Oncology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Department of Genetics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA.
Int J Mol Sci. 2024 Nov 27;25(23):12736. doi: 10.3390/ijms252312736.
Atherosclerosis and cardiovascular disease are associated with high morbidity and mortality in industrialized nations. The Tyro3, Axl, and Mer (TAM) family of receptor tyrosine kinases is involved in the amplification or resolution of atherosclerosis pathology and other cardiovascular pathology. The ligands of these receptors, Protein S (PS) and growth arrest specific protein 6 (Gas6), are essential for TAM receptor functions in the amplification and resolution of atherosclerosis. The Axl-Gas6 interaction has various effects on cardiovascular disease. Mer and PS dampen inflammation, thereby protecting against atherosclerosis progression. Tyro3, the least studied TAM receptor in cardiovascular disease, appears to protect against fibrosis in post-myocardial infarction injury. Ultimately, PS, Gas6, and TAM receptors present an exciting avenue of potential therapeutic targets against inflammation associated with atherosclerosis and cardiovascular disease.
在工业化国家，动脉粥样硬化和心血管疾病与高发病率和高死亡率相关。受体酪氨酸激酶的Tyro3、Axl和Mer（TAM）家族参与动脉粥样硬化病理及其他心血管病理的加剧或消退过程。这些受体的配体，即蛋白S（PS）和生长停滞特异性蛋白6（Gas6），对于TAM受体在动脉粥样硬化加剧和消退过程中的功能至关重要。Axl与Gas6的相互作用对心血管疾病有多种影响。Mer和PS可减轻炎症，从而预防动脉粥样硬化进展。Tyro3是在心血管疾病中研究最少的TAM受体，它似乎可预防心肌梗死后损伤中的纤维化。最终，PS、Gas6和TAM受体为对抗与动脉粥样硬化和心血管疾病相关的炎症提供了一个令人兴奋的潜在治疗靶点途径。
