Deutinger J, Bartl W, Pfersmann C, Neumark J, Bernaschek G
Second Department of Obstetrics and Gynecology, University of Vienna, Austria.
J Perinat Med. 1987;15(3):307-15. doi: 10.1515/jpme.1987.15.3.307.
The amount of amniotic fluid has a close correlation to the function of the fetal renal system. In many cases of fetal growth retardation oligohydramnios is obvious. The aim of this study is the investigation of the hourly fetal urine production rate (HFUPR) and the growth of fetal kidneys during pregnancy in cases of fetal growth retardation and to evaluate the renal participation in the origin of oligohydramnios in cases of growth retardation. In 52 healthy pregnancies and 27 cases with known fetal growth retardation, the volume of the fetal kidneys was measured sonographically and the hourly rate of fetal urine production was determined. Two third of the patients with fetal growth retardation had obvious oligohydramnios. In cases of fetal growth retardation the volume of the fetal kidneys was significantly smaller when compared to the control group, and the volume of fetal urine production was significantly lower. The reduced perfusion of the fetal kidneys in those cases with fetal growth retardation may be the reason for the reduction of the HFUPR. Due to the fact that HFUPR is a dynamical parameter and in close relationship to the perfusion of the fetal kidneys, the identification and measurement of this parameter may help to detect subacute and imminent fetal distress in cases of sonographically proven fetal growth retardation.
羊水的量与胎儿泌尿系统的功能密切相关。在许多胎儿生长受限的病例中，羊水过少很明显。本研究的目的是调查胎儿生长受限病例中胎儿每小时尿液生成率（HFUPR）以及孕期胎儿肾脏的生长情况，并评估肾脏在生长受限病例中羊水过少成因中的作用。对52例正常妊娠和27例已知胎儿生长受限的病例，通过超声测量胎儿肾脏体积并测定胎儿每小时尿液生成率。三分之二的胎儿生长受限患者有明显的羊水过少。与对照组相比，胎儿生长受限病例中胎儿肾脏体积明显较小，胎儿尿液生成量也明显较低。胎儿生长受限病例中胎儿肾脏灌注减少可能是HFUPR降低的原因。由于HFUPR是一个动态参数且与胎儿肾脏灌注密切相关，识别和测量该参数可能有助于在超声证实胎儿生长受限时检测亚急性和即将发生的胎儿窘迫。
