Department of Cell Biology and Histology, Faculty of Biology, Immunobiology for Aquaculture Group, University of Murcia, Murcia, Spain.
J Fish Dis. 2021 Feb;44(2):123-139. doi: 10.1111/jfd.13310. Epub 2020 Nov 25.
Inflammation is a crucial step in the development of chronic diseases in humans. Understanding the inflammation environment and its intrinsic mechanisms when it is produced by harmful stimuli may be a key element in the development of human disease diagnosis. In recent decades, zebrafish (Danio rerio) have been widely used in research, due to their exceptional characteristics, as a model of various human diseases. Interestingly, the mediators released during the inflammatory response of both the immune system and nervous system, after its integration in the hypothalamus, could also facilitate the detection of injury through the register of behavioural changes in the fish. Although there are many studies that give well-defined information separately on such elements as the recruitment of cells, the release of pro- and anti-inflammatory mediators or the type of neurotransmitters released against different triggers, to the best of our knowledge there are no reviews that put all this knowledge together. In the present review, the main available information on inflammation in zebrafish is presented in order to facilitate knowledge about this important process of innate immunity, as well as the stress responses and behavioural changes derived from it.
炎症是人类慢性疾病发展过程中的关键步骤。了解有害刺激产生时的炎症环境及其内在机制，可能是开发人类疾病诊断方法的关键要素。近几十年来，由于其独特的特性，斑马鱼（Danio rerio）已被广泛用于研究，作为各种人类疾病的模型。有趣的是，免疫系统和神经系统在炎症反应中释放的介质，在整合到下丘脑后，也可以通过鱼类行为变化的记录来促进对损伤的检测。尽管有许多研究分别详细介绍了细胞募集、促炎和抗炎介质的释放或针对不同触发因素释放的神经递质类型等方面的信息，但据我们所知，没有综述将所有这些知识汇集在一起。在本综述中，介绍了斑马鱼炎症的主要现有信息，以便于了解这种重要的先天免疫过程以及由此产生的应激反应和行为变化。
