Pendik State Hospital, Chest Diseases Clinic, Istanbul, Turkey.
Division of Immunology and Allergy, Department of Chest Diseases, University of Health Sciences Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
Dermatol Ther. 2021 Jan;34(1):e14581. doi: 10.1111/dth.14581. Epub 2020 Dec 1.
There are conflicting results in the literature regarding the frequency of allergic diseases in COVID-19 patients. The effect of having an allergic disease on COVID-19 disease severity has been little studied.
In this study, we tried to determine the frequency of allergic diseases in COVID-19 patients and the effect of having an allergic disease on COVID-19 disease severity.
DESIGN/METHOD: A retrospective cross-sectional study was conducted in patients diagnosed with COVID-19 in a state hospital in Istanbul, Turkey. Patients were contacted by phone and those who approved to participate in the study were questioned about their sociodemographic characteristics, body mass index, smoking history, and about their atopic status. Rate of atopic diseases among mild and severe COVID-19 patients and risk estimates for mild disease in atopic and non-atopic COVID-19 patients were calculated.
Study population consisted of 235 adults with COVID-19 (mean age, 45.3 years [standard deviation, 15.0 years]; 139 [59.1%] male). Among study population, 16 (6.8%) subjects had one of the three atopic symptoms, which were wheezing, rhinitis, or eczema. Among the subjects with atopic status, four (1.7%) subjects had wheezing, eight (3.4%) had rhinitis, and four (1.7%) had eczema within the last 12 months. Although atopic status is associated with 3.1 times higher odds for mild disease, being atopic or not being atopic was not found to be associated with COVID-19 severity (P = .054).
The information that atopic diseases are less common in COVID-19 patients may guide clinical risk classification.
关于 COVID-19 患者过敏疾病的频率，文献中存在相互矛盾的结果。患有过敏疾病对 COVID-19 疾病严重程度的影响尚未得到充分研究。
在这项研究中，我们试图确定 COVID-19 患者中过敏疾病的频率以及患有过敏疾病对 COVID-19 疾病严重程度的影响。
设计/方法：在土耳其伊斯坦布尔的一家州立医院对 COVID-19 患者进行了回顾性横断面研究。通过电话联系患者，对那些同意参与研究的患者询问其社会人口统计学特征、体重指数、吸烟史以及过敏状况。计算了轻症和重症 COVID-19 患者中过敏性疾病的发病率和过敏性及非过敏性 COVID-19 患者轻症的风险估计值。
研究人群由 235 名患有 COVID-19 的成年人组成（平均年龄为 45.3 岁[标准差为 15.0 岁]；139 名[59.1%]为男性）。在研究人群中，有 16 名（6.8%）患者有三种过敏性症状之一，即喘息、鼻炎或湿疹。在有过敏史的患者中，有 4 名（1.7%）患者在过去 12 个月内有喘息，8 名（3.4%）有鼻炎，4 名（1.7%）有湿疹。尽管过敏状态与轻症的发生几率高 3.1 倍，但过敏或非过敏与 COVID-19 的严重程度无关（P=0.054）。
过敏疾病在 COVID-19 患者中较少见的信息可能有助于临床风险分类。
