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Iron Accumulation, Not β-Amyloid or Brain Volumes, Is Linked to Cognition in Older Patients Who Are Nondemented.

作者信息

Chiang Gloria C

机构信息

From the Department of Radiology, Division of Neuroradiology, NewYork-Presbyterian/Weill Cornell Medical Center, 525 E 68th St, Starr Pavilion, Box 141, New York, NY 10065.

出版信息

Radiology. 2021 Feb;298(2):363-364. doi: 10.1148/radiol.2020204157. Epub 2020 Nov 24.

DOI:10.1148/radiol.2020204157
PMID:33236959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7853849/
Abstract
摘要

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本文引用的文献

1
Quantitative Susceptibility Mapping of Brain Iron and β-Amyloid in MRI and PET Relating to Cognitive Performance in Cognitively Normal Older Adults.脑铁和β-淀粉样蛋白的定量磁敏感映射与认知正常老年人认知表现的 MRI 和 PET 相关。
Radiology. 2021 Feb;298(2):353-362. doi: 10.1148/radiol.2020201603. Epub 2020 Nov 24.
2
NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease.NIA-AA 研究框架：迈向阿尔茨海默病的生物学定义。
Alzheimers Dement. 2018 Apr;14(4):535-562. doi: 10.1016/j.jalz.2018.02.018.
3
Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline.脑定量磁敏感图预测与淀粉样β相关的认知下降。
Brain. 2017 Aug 1;140(8):2112-2119. doi: 10.1093/brain/awx137.
4
Quantitative susceptibility mapping to evaluate the early stage of Alzheimer's disease.定量磁敏感图评估阿尔茨海默病早期。
Neuroimage Clin. 2017 Aug 24;16:429-438. doi: 10.1016/j.nicl.2017.08.019. eCollection 2017.
5
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.无痴呆症人群中脑淀粉样病变的患病率：一项荟萃分析。
JAMA. 2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668.
6
Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis.阿尔茨海默病血清、脑脊液及特定脑区中铁分布紊乱：一项系统评价和荟萃分析
J Alzheimers Dis. 2014;42(2):679-90. doi: 10.3233/JAD-140396.
7
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain.去铁胺抑制阿尔茨海默病转基因小鼠脑内铁诱导的海马 tau 磷酸化。
Neurochem Int. 2013 Jan;62(2):165-72. doi: 10.1016/j.neuint.2012.12.005. Epub 2012 Dec 20.
8
In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals.阿尔茨海默病中神经原纤维缠结和老年斑的原位氧化催化作用：结合态过渡金属的核心作用
J Neurochem. 2000 Jan;74(1):270-9. doi: 10.1046/j.1471-4159.2000.0740270.x.
9
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals.阿尔茨海默病中的铁积累是氧化还原产生的自由基的一个来源。
Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9866-8. doi: 10.1073/pnas.94.18.9866.
10
Intramuscular desferrioxamine in patients with Alzheimer's disease.阿尔茨海默病患者的肌肉注射去铁胺
Lancet. 1991 Jun 1;337(8753):1304-8. doi: 10.1016/0140-6736(91)92978-b.