Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA.
McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO 63108, USA.
Nucleic Acids Res. 2021 Jan 8;49(D1):D1144-D1151. doi: 10.1093/nar/gkaa1084.
The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that provides information on drug-gene interactions and druggable genes from publications, databases, and other web-based sources. Drug, gene, and interaction data are normalized and merged into conceptual groups. The information contained in this resource is available to users through a straightforward search interface, an application programming interface (API), and TSV data downloads. DGIdb 4.0 is the latest major version release of this database. A primary focus of this update was integration with crowdsourced efforts, leveraging the Drug Target Commons for community-contributed interaction data, Wikidata to facilitate term normalization, and export to NDEx for drug-gene interaction network representations. Seven new sources have been added since the last major version release, bringing the total number of sources included to 41. Of the previously aggregated sources, 15 have been updated. DGIdb 4.0 also includes improvements to the process of drug normalization and grouping of imported sources. Other notable updates include the introduction of a more sophisticated Query Score for interaction search results, an updated Interaction Score, the inclusion of interaction directionality, and several additional improvements to search features, data releases, licensing documentation and the application framework.
药物-基因相互作用数据库（DGIdb，www.dgidb.org）是一个网络资源，提供来自出版物、数据库和其他基于网络的来源的药物-基因相互作用和可用药基因的信息。药物、基因和相互作用数据经过规范化和合并到概念组中。用户可以通过简单的搜索界面、应用程序编程接口 (API) 和 TSV 数据下载访问此资源中的信息。DGIdb 4.0 是该数据库的最新主要版本发布。此更新的主要重点是与众包工作的集成，利用药物靶向 Commons 提供社区贡献的相互作用数据、Wikidata 促进术语规范化，并导出到 NDEx 以表示药物-基因相互作用网络。自上次主要版本发布以来，又增加了七个新来源，使包括的来源总数达到 41 个。在之前聚合的来源中，有 15 个已更新。DGIdb 4.0 还改进了药物规范化和导入来源分组的过程。其他值得注意的更新包括引入更复杂的交互搜索结果查询评分、更新的交互评分、包含交互方向性，以及搜索功能、数据发布、许可文档和应用程序框架的几个额外改进。
