The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute.
Ophthalmic Biophysics, L V Prasad Eye Institute, Hyderabad, India.
Ophthalmic Plast Reconstr Surg. 2021;37(4):341-345. doi: 10.1097/IOP.0000000000001863.
To assess the relationship between age at presentation and outcomes of patients with periocular sebaceous gland carcinoma.
Retrospective case series of 241 patients.
Of 241 cases, 29 (12%) were young adults (≤40 years), 122 (51%) were middle-aged adults (41-60 years), and 90 (37%) were older adults (>60 years). Based on the eighth edition of American Joint Committee on Cancer, most tumors belonged to T1 category (n = 78, 32%) on presentation. Wide excisional biopsy was the most common treatment modality (n = 183, 79%). There were no statistically significant differences in the clinical presentation, treatment approaches, and histopathology features amongst different age groups, except pagetoid spread which was higher in middle-aged adults (61%, p = 0.004). The incidence of tumor recurrence was higher in older age group compared to younger age groups, with 5-year, 10-year Kaplan-Meier estimate at 31%, 31% in young adults, 38%, 38% in middle-aged adults, and 45%, 100% in older adults (p = 0.03), respectively. The 10-year Kaplan-Meier estimate rate of locoregional lymph node metastasis, systemic metastasis, and death was higher in young adults (51%, 48%, and 48%, respectively) compared to middle-aged (30%, 17%, and 12%, respectively) and older adults (24%, 25%, and 27%, respectively), but the differences were not statistically significant.
There is no difference in the clinical presentation of periocular sebaceous gland carcinoma based on age. However, the tumor recurrence rate is much higher in the older age group and death higher in younger patients despite the same treatment strategies in all age groups.
评估患者发病年龄与眼周皮脂腺癌结局的关系。
回顾性病例系列研究 241 例患者。
241 例患者中，29 例（12%）为青年（≤40 岁），122 例（51%）为中年（41-60 岁），90 例（37%）为老年（>60 岁）。根据第八版美国癌症联合委员会（AJCC）分期，就诊时大多数肿瘤属于 T1 期（n=78，32%）。广泛切除术是最常见的治疗方式（n=183，79%）。不同年龄组之间，临床表现、治疗方法和组织病理学特征无统计学差异，除中年组中存在更高的 paget 样播散（61%，p=0.004）外。与年轻年龄组相比，老年年龄组的肿瘤复发率更高，5 年和 10 年 Kaplan-Meier 估计分别为 31%、31%在青年组，38%、38%在中年组，45%、100%在老年组（p=0.03）。年轻组（51%、48%和 48%）的局部区域淋巴结转移、全身转移和死亡的 10 年 Kaplan-Meier 估计率高于中年组（30%、17%和 12%）和老年组（24%、25%和 27%），但差异无统计学意义。
根据年龄，眼周皮脂腺癌的临床表现并无差异。然而，老年组的肿瘤复发率更高，年轻患者的死亡率更高，尽管所有年龄组的治疗策略相同。
