Inner Mongolia Key Laboratory of Environmental Pollution Control and Waste Resource Reuse, School of Ecology and Environment, Inner Mongolia University, Hohhot, China.
Department of Applied Chemistry, College of Science, China Agricultural University, Beijing, China.
Environ Toxicol Chem. 2021 Apr;40(4):1007-1016. doi: 10.1002/etc.4943. Epub 2021 Mar 10.
Indoxacarb is a typical chiral insecticide widely used in agricultural pest control. In the present study, zebrafish was used as a model animal to explore the enantioselective bioaccumulation behavior of indoxacarb to nontarget species in aquatic environments. Zebrafish were exposed to 0.025 and 0.1 mg/L rac-indoxacarb solution for 12 d under the semistatic method, and the bioconcentration factor (BCF) and enantiomeric fraction of zebrafish were investigated. The results showed that the (-)-R-indoxacarb preferentially accumulated in zebrafish. The BCF values at 0.025 mg/L exposure levels were 1079.8 and 83.4 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 12 d, respectively. The BCF values at 0.1 mg/L exposure levels were 1752.1 and 137.0 L/kg for (-)-R-indoxacarb and (+)-S-indoxacarb after 10 d, respectively. The half-life values of (-)-R-indoxacarb and (+)-S-indoxacarb were 3.47 and 2.05 d for 0.025 mg/L concentration exposure and 4.95 and 2.66 d for 0.1 mg/L concentration exposure, respectively. The enantiomeric fraction values were in the range of 0.48 to 0.55 and 0.89 to 1.00 for water and zebrafish samples, respectively. Studies on the enantioselective bioaccumulation behavior of indoxacarb will provide data for assessing the environmental fate and potential toxic effects of indoxacarb on aquatic organisms. Environ Toxicol Chem 2021;40:1007-1016. © 2020 SETAC.
茚虫威是一种广泛用于农业害虫防治的典型手性杀虫剂。本研究以斑马鱼为模型动物，探讨了茚虫威在水生环境中对非靶标物种的对映体选择性生物累积行为。斑马鱼在半静态条件下分别暴露于 0.025 和 0.1mg/L 的 rac-茚虫威溶液中 12d，研究了生物浓缩因子（BCF）和斑马鱼的对映体分数。结果表明，（-）-R-茚虫威优先在斑马鱼中积累。在 0.025mg/L 暴露水平下，12d 后（-）-R-茚虫威和（+）-S-茚虫威的 BCF 值分别为 1079.8 和 83.4L/kg；在 0.1mg/L 暴露水平下，10d 后（-）-R-茚虫威和（+）-S-茚虫威的 BCF 值分别为 1752.1 和 137.0L/kg。（-）-R-茚虫威和（+）-S-茚虫威的半衰期值在 0.025mg/L 浓度暴露下分别为 3.47 和 2.05d，在 0.1mg/L 浓度暴露下分别为 4.95 和 2.66d。水和斑马鱼样本中的对映体分数值分别在 0.48 到 0.55 和 0.89 到 1.00 范围内。茚虫威对映体选择性生物累积行为的研究将为评估茚虫威在水生生物中的环境归宿和潜在毒性效应提供数据。Environ Toxicol Chem 2021；40：1007-1016。 © 2020 SETAC。
