Molecular Biology Research Center and Hunan Province Key Laboratory of Basic and Applied Hematology, School of Life Sciences, Central South University, Xiangya Road No. 110, Changsha 410078, Hunan, China.
The Third Xiangya Hospital, Central South University, Tongzipo Road No. 138, Changsha 410013, Hunan, China.
Pathog Dis. 2021 Jan 6;79(1). doi: 10.1093/femspd/ftaa073.
biomarkers can be helpful in identifying patients who may profit by explicit treatments or evaluating the reaction to the treatment of specific disease. Finding unique biomarkers in the process of disease could help clinicians in identifying serious disease in the early stage, so as to improve prognosis.
these investigations, nonetheless, have made constrained progress. Numerous infections are known to cause intense viral encephalitis (VE) in people which can cause a variable level of meningeal just as parenchymal aggravation. Initial clinical manifestations in most encephalitis are nonspecific, resembling a viral-like illness. However, with disease progression, symptoms can become quite severe and fatal, including prominent cranial hypertension, cognitive problems, cerebral hernia and respiratory failure. Forwards: the clinical and research center discoveries in huge numbers of those viral issues are to a great extent comparable and in this way increasingly explicit biomarkers for indicative and prognostic intentions are justified. These biomarkers are progressively significant in the acknowledgment and treatment of the viral central nervous system (CNS) issue.
Clinical manifestations have been the indicative approaches for analysis of viral encephalitis. Lots of studies have been endeavored to distinguish progressively objective laboratory-based quantitative CSF biomarkers for VE.
生物标志物可以帮助识别可能受益于明确治疗的患者,或评估特定疾病的治疗反应。在疾病的过程中发现独特的生物标志物可以帮助临床医生在早期识别严重疾病,从而改善预后。
然而,这些研究进展有限。许多感染已知会导致人类强烈的病毒性脑炎(VE),从而导致不同程度的脑膜和实质恶化。大多数脑炎的初始临床表现是非特异性的,类似于病毒性疾病。然而,随着疾病的进展,症状可能会变得非常严重和致命,包括明显的颅内压升高、认知问题、脑疝和呼吸衰竭。
在大量这些病毒性问题的临床和研究中心发现中,大多数发现是相似的,因此,为了指示和预后目的,越来越明确的生物标志物是合理的。这些生物标志物在病毒性中枢神经系统(CNS)疾病的识别和治疗中越来越重要。
临床表现一直是病毒性脑炎分析的指示方法。已经有很多研究试图区分更客观的基于实验室的定量 CSF 生物标志物用于 VE。