Prognostic significance of autophagy-related genes and in ovarian cancer: a meta-analysis.

OBJECTIVE

Beclin1 plays a central role in the activation of the autophagy signaling pathway. Beclin1 and LC3-related proteins are involved in the initial steps of autophagy, which are closely related to the occurrence and development of tumors. The current meta-analysis aimed to clarify the correlation between expression of and and prognosis of ovarian cancer.

METHODS

We searched PubMed, Embase, The Cochrane Library, Web of Science, and CNKI using predefined selection criteria. Pooled hazard ratios and relative risks with 95% confidence intervals were used to evaluate the correlation between autophagy-related genes and and overall survival (OS), progression-free survival (PFS), and International Federation of Gynecology and Obstetrics (FIGO) stage.

RESULTS

In total, 1497 patients from 10 articles were enrolled in this meta-analysis. Expression of was significantly correlated with improved OS and PFS, and increased expression of was correlated with early FIGO stage, but not with lymph node metastasis or histological grade. No association was found between expression and prognosis in patients with ovarian cancer.

CONCLUSIONS

Expression of is an independent risk factor for the progression of ovarian cancer. Thus, is a promising indicator in predicting prognosis in patients with ovarian cancer.