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自噬相关基因和在卵巢癌中的预后意义：荟萃分析。

Prognostic significance of autophagy-related genes and in ovarian cancer: a meta-analysis.

机构信息

Department of Gynecology, Fujian Cancer Hospital, Affiliated Cancer Hospital of 74551Fujian Medical University, Fuzhou, Fujian, China.

Department of Gynecology, Shengli Clinical Medical College of 74551Fujian Medical University, Fuzhou, Fujian, China.

出版信息

J Int Med Res. 2020 Nov;48(11):300060520968299. doi: 10.1177/0300060520968299.

DOI:10.1177/0300060520968299
PMID:33238786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7705295/
Abstract

OBJECTIVE

Beclin1 plays a central role in the activation of the autophagy signaling pathway. Beclin1 and LC3-related proteins are involved in the initial steps of autophagy, which are closely related to the occurrence and development of tumors. The current meta-analysis aimed to clarify the correlation between expression of and and prognosis of ovarian cancer.

METHODS

We searched PubMed, Embase, The Cochrane Library, Web of Science, and CNKI using predefined selection criteria. Pooled hazard ratios and relative risks with 95% confidence intervals were used to evaluate the correlation between autophagy-related genes and and overall survival (OS), progression-free survival (PFS), and International Federation of Gynecology and Obstetrics (FIGO) stage.

RESULTS

In total, 1497 patients from 10 articles were enrolled in this meta-analysis. Expression of was significantly correlated with improved OS and PFS, and increased expression of was correlated with early FIGO stage, but not with lymph node metastasis or histological grade. No association was found between expression and prognosis in patients with ovarian cancer.

CONCLUSIONS

Expression of is an independent risk factor for the progression of ovarian cancer. Thus, is a promising indicator in predicting prognosis in patients with ovarian cancer.

摘要

目的

Beclin1 在自噬信号通路的激活中起核心作用。Beclin1 和 LC3 相关蛋白参与自噬的初始步骤，与肿瘤的发生和发展密切相关。本荟萃分析旨在阐明与卵巢癌预后相关的和表达之间的相关性。

方法

我们使用预设的选择标准在 PubMed、Embase、The Cochrane Library、Web of Science 和 CNKI 中进行了搜索。使用合并风险比和 95%置信区间来评估自噬相关基因和与总生存期 (OS)、无进展生存期 (PFS) 和国际妇产科联盟 (FIGO) 分期之间的相关性。

结果

总共纳入了 10 篇文章中的 1497 名患者进行了这项荟萃分析。的表达与 OS 和 PFS 的改善显著相关，而的高表达与 FIGO 早期分期相关，但与淋巴结转移或组织学分级无关。在卵巢癌患者中，表达与预后之间没有关联。

结论

的表达是卵巢癌进展的独立危险因素。因此，在预测卵巢癌患者的预后方面，是一个很有前途的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/514d2f7a4846/10.1177_0300060520968299-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/25fed2f4133c/10.1177_0300060520968299-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/df085ec9fd21/10.1177_0300060520968299-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/75c8358dc451/10.1177_0300060520968299-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/aac17fcd3750/10.1177_0300060520968299-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/e8f6381b700f/10.1177_0300060520968299-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/c7897c92211b/10.1177_0300060520968299-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/c4d264c102a0/10.1177_0300060520968299-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/514d2f7a4846/10.1177_0300060520968299-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/25fed2f4133c/10.1177_0300060520968299-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/df085ec9fd21/10.1177_0300060520968299-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/75c8358dc451/10.1177_0300060520968299-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/aac17fcd3750/10.1177_0300060520968299-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/e8f6381b700f/10.1177_0300060520968299-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/c7897c92211b/10.1177_0300060520968299-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/c4d264c102a0/10.1177_0300060520968299-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eca/7705295/514d2f7a4846/10.1177_0300060520968299-fig8.jpg

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