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MyomiRs 在心脏发育和相关疾病中的潜在作用。

Potential Roles of MyomiRs in Cardiac Development and Related Diseases.

机构信息

Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Department of Biochemistry and Genetics, School of Medicine, Lorestan University of Medical Science, Khorramabad, Iran.

出版信息

Curr Cardiol Rev. 2021;17(4):e010621188335. doi: 10.2174/1573403X16999201124201021.

DOI:10.2174/1573403X16999201124201021
PMID:33238844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8762156/
Abstract

Muscle-specific miRNAs, which are known as MyomiRs, are crucial regulatory elements for cardiovascular development. MyomiRs are abundantly expressed in the myocardium and regulate certain aspects of physiological and pathological processes in myocardiocytes, including cardiovascular development, myocardial remodeling, and arise for cardiovascular diseases through different mechanisms, such as epigenetic pathways. Clinical and experimental studies have confirmed the myomiRs as promising diagnostic biomarkers for the early diagnosis of cardiac disorders. In this review, we have summarized recent findings in the field of epigenetic modulations of myomiRs and cardiac regeneration associated with cardiac diseases.

摘要

肌特异性 microRNAs（miRNAs），也被称为 MyomiRs，是心血管发育的关键调控因子。MyomiRs 在心肌中大量表达，调节心肌细胞生理和病理过程的某些方面，包括心血管发育、心肌重构等。它们通过不同的机制，如表观遗传途径，引发心血管疾病。临床和实验研究已经证实，miRs 作为心脏疾病早期诊断的有前途的诊断生物标志物。在这篇综述中，我们总结了与心脏疾病相关的肌特异性 miRNAs 及其与心脏再生的表观遗传调控的最新发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/36c8d7b53c1a/CCR-17-e010621188335_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/91e22ceeca59/CCR-17-e010621188335_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/f70d11506071/CCR-17-e010621188335_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/add6c99fcb97/CCR-17-e010621188335_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/36c8d7b53c1a/CCR-17-e010621188335_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/91e22ceeca59/CCR-17-e010621188335_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/f70d11506071/CCR-17-e010621188335_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/add6c99fcb97/CCR-17-e010621188335_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/8762156/36c8d7b53c1a/CCR-17-e010621188335_F4.jpg

相似文献

[1]
Potential Roles of MyomiRs in Cardiac Development and Related Diseases.

Curr Cardiol Rev. 2021

[2]
MicroRNAs differentially regulated in cardiac and skeletal muscle in health and disease: potential drug targets?

Clin Exp Pharmacol Physiol. 2014-9

[3]
Small molecule inhibitor of myogenic microRNAs leads to a discovery of miR-221/222-myoD-myomiRs regulatory pathway.

Chem Biol. 2014-10-23

[4]
Evolution and Distribution of Teleost myomiRNAs: Functionally Diversified myomiRs in Teleosts.

Mar Biotechnol (NY). 2016-6

[5]
Circulating myomiRs: a new class of biomarkers to monitor skeletal muscle in physiology and medicine.

J Cachexia Sarcopenia Muscle. 2017-11-28

[6]
MicroRNAs in cardiac regeneration and cardiovascular disease.

Sci China Life Sci. 2013-8-22

[7]
Dysregulated expression profile of myomiRs in the skeletal muscle of patients with polymyositis.

EJIFCC. 2019-6-24

[8]
MicroRNAs in cardiac remodeling and disease.

J Cardiovasc Transl Res. 2010-2-17

[9]
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease.

World J Biol Chem. 2015-8-26

[10]
Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction).

J Mol Cell Cardiol. 2016-5

引用本文的文献

[1]
Roles of Long Non-Coding RNAs in the Pathogenesis of Cardiovascular Disorders: Challenges and Opportunities.

J Cardiovasc Transl Res. 2025-8-18

[2]
The Potential Contribution of MyomiRs miR-133a-3p, -133b, and -206 Dysregulation in Cardiovascular Disease Risk.

Int J Mol Sci. 2024-11-27

[3]
Transforming Cardiotoxicity Detection in Cancer Therapies: The Promise of MicroRNAs as Precision Biomarkers.

Int J Mol Sci. 2024-11-6

[4]
A Glimpse of Noncoding RNAs: Secondary Structure, Emerging Trends, and Potential Applications in Human Diseases.

Methods Mol Biol. 2025

[5]
miRNAs in the diagnosis and therapy of cardiac and mediastinal tumors: a new dawn for cardio-oncology?

Future Cardiol. 2024

[6]
miRNAs in Heart Development and Disease.

Int J Mol Sci. 2024-1-30

[7]
MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment.

Int J Mol Sci. 2023-11-11

[8]
Integrated small RNA, mRNA and protein omics reveal a miRNA network orchestrating metabolic maturation of the developing human heart.

BMC Genomics. 2023-11-23

[9]
Regulation of HIF-1 by MicroRNAs in Various Cardiovascular Diseases.

Curr Cardiol Rev. 2023

[10]
A panel of blood-derived miRNAs with a stable expression pattern as a potential pan-cancer detection signature.

Front Mol Biosci. 2022-12-15

本文引用的文献

[1]
Applications of miRNAs in cardiac development, disease progression and regeneration.

Stem Cell Res Ther. 2019-11-21

[2]
miR-486 is modulated by stretch and increases ventricular growth.

JCI Insight. 2019-9-12

[3]
Noncoding RNAs in Hypertension.

Hypertension. 2019-9

[4]
The role of microRNAs in congenital heart disease.

EJIFCC. 2019-6-24

[5]
Transient induction of Cdk9 in the early stage of differentiation is critical for myogenesis.

J Cell Biochem. 2019-6-30

[6]
miR-1, miR-499 and miR-208 are sensitive markers to diagnose sudden death due to early acute myocardial infarction.

J Cell Mol Med. 2019-6-26

[7]
miR-155 in the Resolution of Atherosclerosis.

Front Pharmacol. 2019-5-14

[8]
Interplay between miRNAs and host genes and their role in cancer.

Brief Funct Genomics. 2018-7-22

[9]
The diagnostic value of circulating microRNAs in heart failure.

Exp Ther Med. 2019-3

[10]
Role of miRNAs on the Pathophysiology of Cardiovascular Diseases.

Arq Bras Cardiol. 2018-11

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