微小 RNA 与心脏再生和心血管疾病。
MicroRNAs in cardiac regeneration and cardiovascular disease.
机构信息
Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
出版信息
Sci China Life Sci. 2013 Oct;56(10):907-13. doi: 10.1007/s11427-013-4534-9. Epub 2013 Aug 22.
Abstract
microRNAs (miRNAs) are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes. miRNAs have been demonstrated essential to normal cardiac development and function. Recently, numerous studies indicate miRNAs are involved in cardiac regeneration and cardiac disease, including cardiac hypertrophy, myocardial infarction and cardiac arrhythmia. These observations suggest miRNAs play important roles in cardiology. In this review, we summarize the recent progress of studying miRNAs in cardiac regeneration and cardiac disease. We also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.
摘要
microRNAs (miRNAs) 是一类小的非编码 RNA，通过转录后调控蛋白编码基因的表达，在广泛的生物学过程中发挥重要作用。miRNAs 对正常心脏发育和功能至关重要。最近，大量研究表明 miRNAs 参与心脏再生和心脏疾病，包括心脏肥大、心肌梗死和心律失常。这些观察结果表明 miRNAs 在心脏病学中发挥重要作用。在这篇综述中，我们总结了 miRNA 在心脏再生和心脏疾病研究方面的最新进展。我们还讨论了 miRNAs 在心脏病诊断和治疗方面的潜在应用。
相似文献
1
MicroRNAs in cardiac regeneration and cardiovascular disease.微小 RNA 与心脏再生和心血管疾病。
Sci China Life Sci. 2013 Oct;56(10):907-13. doi: 10.1007/s11427-013-4534-9. Epub 2013 Aug 22.
2
MicroRNAs in cardiac remodeling and disease.微小 RNA 在心脏重构和疾病中的作用。
J Cardiovasc Transl Res. 2010 Jun;3(3):212-8. doi: 10.1007/s12265-010-9165-y. Epub 2010 Feb 17.
3
Small engine, big power: microRNAs as regulators of cardiac diseases and regeneration.小引擎，大动力：微小RNA作为心脏疾病和再生的调节因子
Int J Mol Sci. 2014 Sep 9;15(9):15891-911. doi: 10.3390/ijms150915891.
4
Role of microRNAs in cardiac hypertrophy and heart failure.微小RNA在心肌肥厚和心力衰竭中的作用。
IUBMB Life. 2009 Jun;61(6):566-71. doi: 10.1002/iub.204.
5
Macro advances in microRNAs and myocardial regeneration.微小RNA与心肌再生的宏观进展。
Curr Opin Cardiol. 2014 May;29(3):207-13. doi: 10.1097/HCO.0000000000000050.
6
Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction).心脏特异性微小RNA在心脏发生、心脏功能及心脏病理学中的作用（重点关注心肌梗死）
J Mol Cell Cardiol. 2016 May;94:107-121. doi: 10.1016/j.yjmcc.2016.03.015. Epub 2016 Apr 4.
7
Regulation of human cardiac ion channel genes by microRNAs: theoretical perspective and pathophysiological implications.微小RNA对人类心脏离子通道基因的调控：理论观点与病理生理学意义
Cell Physiol Biochem. 2010;25(6):571-86. doi: 10.1159/000315076. Epub 2010 May 18.
8
A miRNA's insight into the regenerating heart: a concise descriptive analysis.miRNA 对心脏再生的洞察：简明描述性分析。
Heart Fail Rev. 2020 Nov;25(6):1047-1061. doi: 10.1007/s10741-019-09896-w.
9
Role of microRNAs in cardiac remodeling and heart failure.微小 RNA 在心脏重构和心力衰竭中的作用。
Cardiovasc Drugs Ther. 2011 Apr;25(2):171-82. doi: 10.1007/s10557-011-6289-5.
10
miRNAs at the heart of the matter.miRNAs是问题的核心。
J Mol Med (Berl). 2008 Jul;86(7):771-83. doi: 10.1007/s00109-008-0341-3. Epub 2008 Apr 16.
引用本文的文献
1
Association of the miR-143 Gene rs353292 Polymorphism with Recurrent Pregnancy Loss in Caucasian Women: A Novel Finding in a Multifactorial Devastating Problem.miR-143 基因 rs353292 多态性与高加索裔女性复发性妊娠丢失的相关性：一种多因素破坏性问题的新发现。
Int J Mol Sci. 2024 Nov 7;25(22):11952. doi: 10.3390/ijms252211952.
2
The Role of Circulating MicroRNAs in Cardiovascular Diseases: A Novel Biomarker for Diagnosis and Potential Therapeutic Targets?循环微RNA在心血管疾病中的作用：一种用于诊断的新型生物标志物及潜在治疗靶点？
Cureus. 2024 Jul 8;16(7):e64100. doi: 10.7759/cureus.64100. eCollection 2024 Jul.
3
In situ reprogramming of cardiac fibroblasts into cardiomyocytes in mouse heart with chemicals.利用化学物质在小鼠心脏中将心脏成纤维细胞原位重编程为心肌细胞。
Acta Pharmacol Sin. 2024 Nov;45(11):2290-2299. doi: 10.1038/s41401-024-01308-6. Epub 2024 Jun 18.
4
Cell-Free Treatments: A New Generation of Targeted Therapies for Treatment of Ischemic Heart Disease.无细胞治疗：治疗缺血性心脏病的新一代靶向疗法。
Cell J. 2022 Jul 27;24(7):353-363. doi: 10.22074/cellj.2022.7643.
5
Light Emitting Diodes Irradiation Regulates miRNA-877-3p to Promote Cardiomyocyte Proliferation.发光二极管照射调节 miRNA-877-3p 促进心肌细胞增殖。
Int J Med Sci. 2022 Jul 11;19(8):1254-1264. doi: 10.7150/ijms.70743. eCollection 2022.
6
Photobiomodulation Drives MiR-136-5p Expression to Promote Injury Repair after Myocardial Infarction.光生物调节驱动 miR-136-5p 的表达，促进心肌梗死后的损伤修复。
Int J Biol Sci. 2022 Apr 18;18(7):2980-2993. doi: 10.7150/ijbs.71440. eCollection 2022.
7
Non-coding RNAs in Cardiac Regeneration.心脏再生中的非编码RNA
Front Physiol. 2021 Mar 24;12:650566. doi: 10.3389/fphys.2021.650566. eCollection 2021.
8
The microRNA and the perspectives of miR-302.微小RNA与miR-302的研究前景
Heliyon. 2019 Jan 25;5(1):e01167. doi: 10.1016/j.heliyon.2019.e01167. eCollection 2019 Jan.
9
Expanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stages.扩展大西洋三文鱼中的 miRNA 谱；在不同组织和发育阶段高度表达的 isomiRs 和 miRNAs 的发现。
Cells. 2019 Jan 11;8(1):42. doi: 10.3390/cells8010042.
10
How cardiomyocytes sense pathophysiological stresses for cardiac remodeling.心肌细胞如何感知导致心脏重塑的病理生理应激。
Cell Mol Life Sci. 2017 Mar;74(6):983-1000. doi: 10.1007/s00018-016-2373-0. Epub 2016 Oct 6.
本文引用的文献
1
Circulating p53-responsive microRNAs are predictive indicators of heart failure after acute myocardial infarction.循环 p53 反应性 microRNAs 是急性心肌梗死后心力衰竭的预测指标。
Circ Res. 2013 Jul 19;113(3):322-6. doi: 10.1161/CIRCRESAHA.113.301209. Epub 2013 Jun 6.
2
mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.miR-17-92 簇对于诱导出生后和成年心脏中的心肌细胞增殖是必需的和充分的。
Circ Res. 2013 Jun 7;112(12):1557-66. doi: 10.1161/CIRCRESAHA.112.300658. Epub 2013 Apr 10.
3
MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.MicroRNA-22 调节心脏应对压力时的肥大和重构。
Circ Res. 2013 Apr 26;112(9):1234-43. doi: 10.1161/CIRCRESAHA.112.300682. Epub 2013 Mar 22.
4
Reprogramming of human fibroblasts toward a cardiac fate.人成纤维细胞向心脏命运的重编程。
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5588-93. doi: 10.1073/pnas.1301019110. Epub 2013 Mar 4.
5
Cardiomyocyte proliferation contributes to heart growth in young humans.心肌细胞增殖有助于人类幼体心脏生长。
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1446-51. doi: 10.1073/pnas.1214608110. Epub 2013 Jan 9.
6
Functional screening identifies miRNAs inducing cardiac regeneration.功能筛选鉴定出诱导心脏再生的 miRNAs。
Nature. 2012 Dec 20;492(7429):376-81. doi: 10.1038/nature11739. Epub 2012 Dec 5.
7
Heart repair by reprogramming non-myocytes with cardiac transcription factors.心脏转录因子对非心肌细胞的重编程实现心脏修复。
Nature. 2012 May 13;485(7400):599-604. doi: 10.1038/nature11139.
8
Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction.靶向敲除 microRNA-22 可促进应激诱导的心脏扩张和收缩功能障碍。
Circulation. 2012 Jun 5;125(22):2751-61. doi: 10.1161/CIRCULATIONAHA.111.044354. Epub 2012 May 8.
9
MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.microRNA 介导的心肌成纤维细胞体外和体内直接重编程为心肌细胞。
Circ Res. 2012 May 25;110(11):1465-73. doi: 10.1161/CIRCRESAHA.112.269035. Epub 2012 Apr 26.
10
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.在体重编程鼠心肌成纤维细胞为诱导性心肌细胞。
Nature. 2012 May 31;485(7400):593-8. doi: 10.1038/nature11044.
Zotero 插件