在孤立性功能肾情况下从根治性肾切除术到部分肾切除术：肾细胞癌的新辅助治疗
From Radical to Partial Nephrectomy in the Setting of Solitary Functioning Kidney: Neoadjuvant Treatment of Renal Cell Carcinoma.
作者信息
Watson David D, Farha Nicole M, Kallail K James, Dakhil Shaker, Farha A J
机构信息
University of Kansas School of Medicine Wichita, KS.
Department of Research, University of Kansas School of Medicine Wichita, KS.
出版信息
Rev Urol. 2020;22(3):126-129.
Abstract
Immunotherapy has revolutionized the treatment of metastatic renal cell carcinoma (RCC). This case evaluates the use of neoadjuvant immunotherapy for localized RCC in a patient with solitary functioning kidney. A retrospective chart review was conducted between September 2019 and January 2020 on a single patient. Before treatment, the tumor was 7 cm × 8 cm × 8.5 cm. The patient trialed nivolumab + ipilimumab then cabozantinib. The tumor shrunk to 6.3 cm × 5.5 cm and was removed via partial nephrectomy. This case demonstrates the efficacy of immunotherapy in neoadjuvant treatment of RCC. Expansion of guidelines could allow for patients with RCC to undergo partial nephrectomy.
摘要
免疫疗法彻底改变了转移性肾细胞癌（RCC）的治疗方式。本病例评估了新辅助免疫疗法在一名单功能肾患者局部RCC治疗中的应用。2019年9月至2020年1月对一名患者进行了回顾性病历审查。治疗前，肿瘤大小为7厘米×8厘米×8.5厘米。患者先试用纳武单抗+伊匹单抗，然后使用卡博替尼。肿瘤缩小至6.3厘米×5.5厘米，并通过部分肾切除术切除。本病例证明了免疫疗法在RCC新辅助治疗中的疗效。指南的扩展可能使RCC患者能够接受部分肾切除术。
相似文献
1
2
Efficacy of Cabozantinib in Metastatic Papillary Renal Cell Carcinoma Following Ineffective Treatment With Initial Therapy of Nivolumab and Ipilimumab.卡博替尼治疗纳武利尤单抗和伊匹单抗初始治疗失败的转移性乳头状肾细胞癌的疗效。
In Vivo. 2021 May-Jun;35(3):1743-1747. doi: 10.21873/invivo.12433.
3
Neoadjuvant Cabozantinib in Renal-Cell Carcinoma: A Brief Review.新辅助卡博替尼治疗肾细胞癌：简要综述。
Clin Genitourin Cancer. 2020 Dec;18(6):e688-e691. doi: 10.1016/j.clgc.2020.04.003. Epub 2020 Apr 21.
4
Neoadjuvant nivolumab and cabozantinib in advanced renal cell carcinoma in a horseshoe kidney - how to achieve a safe and radical resection? a case report and review of the literature.新辅助纳武单抗和卡博替尼治疗马蹄肾晚期肾细胞癌——如何实现安全的根治性切除？病例报告及文献综述
Front Oncol. 2023 Jul 14;13:1115901. doi: 10.3389/fonc.2023.1115901. eCollection 2023.
5
Nonfamilial Bilateral Synchronous Renal Cell Carcinoma with Discordant Histology with Eventual Complete Response to Dual Immunotherapy.非家族性双侧同步性肾细胞癌，组织学表现不一致，最终对双重免疫疗法完全缓解
Case Rep Oncol. 2023 Nov 13;16(1):1378-1383. doi: 10.1159/000533936. eCollection 2023 Jan-Dec.
6
A Phase II Study of Pazopanib in Patients with Localized Renal Cell Carcinoma to Optimize Preservation of Renal Parenchyma.帕唑帕尼治疗局限性肾细胞癌以优化保留肾实质的 II 期研究。
J Urol. 2015 Aug;194(2):297-303. doi: 10.1016/j.juro.2015.03.096. Epub 2015 Mar 23.
7
The Role of Nephrectomy for Kidney Cancer in the Era of Targeted and Immune Therapies.肾切除术在靶向治疗和免疫治疗时代对肾癌的作用
Am Soc Clin Oncol Educ Book. 2016;35:e16-20. doi: 10.1200/EDBK_158977.
8
Neoadjuvant Cabozantinib in an Unresectable Locally Advanced Renal Cell Carcinoma Patient Leads to Downsizing of Tumor Enabling Surgical Resection: A Case Report.新辅助卡博替尼治疗不可切除的局部晚期肾细胞癌患者导致肿瘤缩小从而实现手术切除：一例报告
Front Oncol. 2021 Feb 1;10:622134. doi: 10.3389/fonc.2020.622134. eCollection 2020.
9
Solitary breast mass as initial presentation of clinically silent metastatic renal cell carcinoma.孤立性乳腺肿块作为临床隐匿性转移性肾细胞癌的初始表现。
Breast. 2006 Jun;15(3):427-9. doi: 10.1016/j.breast.2005.09.009. Epub 2005 Nov 9.
10
Complete response of renal cell carcinoma vena cava tumor thrombus to neoadjuvant immunotherapy.肾细胞癌静脉癌栓完全缓解对新辅助免疫治疗的反应。
J Immunother Cancer. 2019 Mar 11;7(1):66. doi: 10.1186/s40425-019-0546-8.
引用本文的文献
1
Neoadjuvant nivolumab and cabozantinib in advanced renal cell carcinoma in a horseshoe kidney - how to achieve a safe and radical resection? a case report and review of the literature.新辅助纳武单抗和卡博替尼治疗马蹄肾晚期肾细胞癌——如何实现安全的根治性切除？病例报告及文献综述
Front Oncol. 2023 Jul 14;13:1115901. doi: 10.3389/fonc.2023.1115901. eCollection 2023.
本文引用的文献
1
US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States.美国肾脏数据系统2018年年报：美国肾脏疾病流行病学
Am J Kidney Dis. 2019 Mar;73(3 Suppl 1):A7-A8. doi: 10.1053/j.ajkd.2019.01.001. Epub 2019 Feb 21.
2
Cabozantinib for the Management of Metastatic Clear Cell Renal Cell Carcinoma.卡博替尼用于转移性透明细胞肾细胞癌的治疗
J Kidney Cancer VHL. 2018 Oct 8;5(4):1-5. doi: 10.15586/jkcvhl.2018.109. eCollection 2018.
3
Current and emerging therapies for first-line treatment of metastatic clear cell renal cell carcinoma.转移性透明细胞肾细胞癌一线治疗的现有和新兴疗法。
Cancer Treat Rev. 2018 Nov;70:127-137. doi: 10.1016/j.ctrv.2018.07.009. Epub 2018 Jul 20.
4
Ipilimumab in combination with nivolumab for the treatment of renal cell carcinoma.依匹单抗联合纳武利尤单抗治疗肾细胞癌。
Expert Opin Biol Ther. 2018 Sep;18(9):947-957. doi: 10.1080/14712598.2018.1513485. Epub 2018 Aug 30.
5
Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma.纳武利尤单抗联合伊匹木单抗与舒尼替尼治疗晚期肾细胞癌的比较
N Engl J Med. 2018 Apr 5;378(14):1277-1290. doi: 10.1056/NEJMoa1712126. Epub 2018 Mar 21.
6
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.免疫检查点抑制剂治疗患者免疫相关不良反应的管理：美国临床肿瘤学会临床实践指南。
J Clin Oncol. 2018 Jun 10;36(17):1714-1768. doi: 10.1200/JCO.2017.77.6385. Epub 2018 Feb 14.
7
Safety and Efficacy of Nivolumab in Combination With Ipilimumab in Metastatic Renal Cell Carcinoma: The CheckMate 016 Study.纳武单抗联合伊匹木单抗治疗转移性肾细胞癌的安全性和疗效：CheckMate 016研究
J Clin Oncol. 2017 Dec 1;35(34):3851-3858. doi: 10.1200/JCO.2016.72.1985. Epub 2017 Jul 5.
8
Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.肾癌，2017 年第 2 版，NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2017 Jun;15(6):804-834. doi: 10.6004/jnccn.2017.0100.
9
Neurologic Serious Adverse Events Associated with Nivolumab Plus Ipilimumab or Nivolumab Alone in Advanced Melanoma, Including a Case Series of Encephalitis.纳武单抗联合伊匹单抗或单独使用纳武单抗治疗晚期黑色素瘤相关的神经系统严重不良事件，包括一组脑炎病例
Oncologist. 2017 Jun;22(6):709-718. doi: 10.1634/theoncologist.2016-0487. Epub 2017 May 11.
10
Cabozantinib Versus Sunitinib As Initial Targeted Therapy for Patients With Metastatic Renal Cell Carcinoma of Poor or Intermediate Risk: The Alliance A031203 CABOSUN Trial.卡博替尼对比舒尼替尼作为低危或中危转移性肾细胞癌患者的初始靶向治疗：联盟A031203 CABOSUN试验
J Clin Oncol. 2017 Feb 20;35(6):591-597. doi: 10.1200/JCO.2016.70.7398. Epub 2016 Nov 14.
Zotero 插件