Benissan-Messan Dathe Z, Zhu Hua, Zhong Weina, Tan Tao, Ma Jianjie, Lee Peter H U
Department of Surgery, The Ohio State University, Columbus, OH, United States.
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, United States.
Front Physiol. 2020 Nov 6;11:583393. doi: 10.3389/fphys.2020.583393. eCollection 2020.
Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein's wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.
自2009年被发现以来，多项研究表明MG53在肌肉生理学中具有重要意义。该蛋白在横纹肌中产生，但其生理影响超出了横纹肌的范围。在肌肉再生、钙稳态、兴奋-收缩偶联、肌发生和线粒体方面的作用突出了该蛋白的广泛影响。从这些生理作用中可能会产生许多治疗应用。本综述总结了目前关于MG53在骨骼肌中作用的文献，并讨论了其治疗应用。
