Chen Boran, Chen Chaoyue, Zheng Junkai, Li Ruoyu, Xu Jianguo
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
West China School of Medicine, Sichuan University, Chengdu, China.
Front Neurol. 2020 Nov 9;11:593520. doi: 10.3389/fneur.2020.593520. eCollection 2020.
This mini review aims to provide insight into the neurological imaging in patients with coronavirus disease 2019 (COVID-19). PubMed, Embase, and Web of Science were searched through July 21, 2020, for relevant studies reporting the neuroimaging findings in COVID-19 patients with neurological manifestations. Proportion estimates with a 95% confidence interval (CI) were pooled after the Freeman-Tukey transformation. The heterogeneity across the included studies was also assessed. Overall, 11 studies with a total of 659 patients were included. The pooled proportion estimate of abnormal neuroimaging finding in patients who exhibited neurological manifestation and underwent brain CT or MRI was 59% (95% CI, 39-77%). The proportions of acute/subacute ischemic infarction, intracranial hemorrhage, and subcortical or deep white matter abnormalities were 22% (95% CI, 17-28%), 24% (95% CI, 17-30%), and 27% (95% CI, 12-45%), respectively. This mini review comprehensively detailed neuroimaging findings of patients with COVID-19 and neurological manifestations. Clinicians should be familiar with the neuroimaging patterns to catch the sight of brain abnormalities caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
本综述旨在深入了解2019冠状病毒病（COVID-19）患者的神经影像学表现。截至2020年7月21日，检索了PubMed、Embase和Web of Science，以查找报告有神经学表现的COVID-19患者神经影像学发现的相关研究。在Freeman-Tukey变换后合并95%置信区间（CI）的比例估计值。还评估了纳入研究之间的异质性。总体而言，纳入了11项研究，共659例患者。有神经学表现并接受脑部CT或MRI检查的患者神经影像学异常发现的合并比例估计为59%（95%CI，39-77%）。急性/亚急性缺血性梗死、颅内出血以及皮质下或深部白质异常的比例分别为22%（95%CI，17-28%）、24%（95%CI，17-30%）和27%（95%CI，12-45%）。本综述全面详细地阐述了有神经学表现的COVID-19患者的神经影像学发现。临床医生应熟悉神经影像学模式，以便发现由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起 的脑部异常。
