Department of General Surgery, Ain Shams University, Cairo, Egypt.
Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Front Endocrinol (Lausanne). 2020 Nov 9;11:569633. doi: 10.3389/fendo.2020.569633. eCollection 2020.
Covid19 is a worldwide pandemic challenge that started in Wuhan, China and spread to almost all countries on the planet within a few months. The causative virus was found to be highly contagious and, until now, considerably difficult to contain. A look at the epidemiological distribution of the disease over the planet has raised a number of questions whose answers could help us understand the behavior of the virus and consequently leads us to possible means of limitation of its spread or even flattening of the curve of morbidity and mortality. After the third decade of life, there is a progressive decline of growth hormone (GH) secretion by approximately 15% for every decade of adult life. The data from highly affected countries suggest a more aggressive course in the elderly, a double-time affection of males more than females, and the vulnerability of some risk groups of patients. Our observation is that GH deficiency is a common factor in all vulnerable patient groups. We think that there is a need for studying the role of growth hormone in the unique epidemiological pattern of Covid-19 so that it might help in the early detection and management of the high-risk groups as appropriate.
Covid19 是一场全球性的大流行病挑战，始于中国武汉，几个月内就蔓延到了地球上几乎所有国家。已发现致病病毒具有高度传染性，而且迄今为止，相当难以控制。对该疾病在全球的流行病学分布的研究提出了一些问题，这些问题的答案可能有助于我们了解病毒的行为，并由此引导我们找到可能的方法来限制其传播，甚至使发病率和死亡率曲线变平。30 岁以后，生长激素（GH）的分泌每十年大约下降 15%。来自受影响严重国家的数据表明，老年人的病情更为严重，男性比女性的发病速度快两倍，某些高危患者群体也容易受到影响。我们观察到，GH 缺乏是所有易感患者群体的共同因素。我们认为，有必要研究生长激素在 Covid-19 这种独特的流行病学模式中的作用，以便能够帮助早期发现和适当管理高危人群。
