Tian Mingfu, Huang Yuqing, Song Yunting, Li Wen, Zhao Peiyi, Liu Weiyong, Wu Kailang, Wu Jianguo
State Key Laboratory of Virology College of Life Sciences Wuhan University Wuhan 430072 China.
Guangdong Provincial Key Laboratory of Virology Institute of Medical Microbiology Jinan University Guangzhou 510632 China.
Adv Sci (Weinh). 2020 Sep 30;7(22):2001950. doi: 10.1002/advs.202001950. eCollection 2020 Nov.
Aging is a universal feature of life that is a major focus of scientific research and a risk factor in many diseases. A comprehensive understanding of the cellular and molecular mechanisms of aging are critical to the prevention of diseases associated with the aging process. Here, it is shown that MYSM1 is a key suppressor of aging and aging-related pathologies. MYSM1 functionally represses cellular senescence and the aging process in human and mice primary cells and in mice organs. MYSM1 mechanistically attenuates the aging process by promoting DNA repair processes. Remarkably, MYSM1 deficiency facilitates the aging process and reduces lifespan, whereas MYSM1 over-expression attenuates the aging process and increases lifespan in mice. The functional role of MYSM1 is demonstrated in suppressing the aging process and prolonging lifespan. MYSM1 is a key suppressor of aging and may act as a potential agent for the prevention of aging and aging-associated diseases.
衰老作为生命的普遍特征，是科学研究的主要焦点以及许多疾病的风险因素。全面了解衰老的细胞和分子机制对于预防与衰老过程相关的疾病至关重要。在此研究中表明，MYSM1是衰老及衰老相关病理的关键抑制因子。MYSM1在功能上可抑制人和小鼠原代细胞以及小鼠器官中的细胞衰老和衰老过程。MYSM1通过促进DNA修复过程在机制上减弱衰老过程。值得注意的是，MYSM1缺陷会加速衰老过程并缩短寿命，而MYSM1过表达则会减弱衰老过程并延长小鼠寿命。MYSM1在抑制衰老过程和延长寿命方面的功能作用得到了证实。MYSM1是衰老的关键抑制因子，可能成为预防衰老及衰老相关疾病的潜在药物。
