Siamof Cerise M, Goel Shreya, Cai Weibo
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, United States.
Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Front Chem. 2020 Nov 10;8:598100. doi: 10.3389/fchem.2020.598100. eCollection 2020.
Nanotechnology has made a significant impact on basic and clinical cancer research over the past two decades. Owing to multidisciplinary advances, cancer nanotechnology aims to address the problems in current cancer treatment paradigms, with the ultimate goal to improve treatment efficacy, increase patient survival, and decrease toxic side-effects. The potential for use of nanomedicine in cancer targeting and therapy has grown, and is now used to advance the four traditional pillars of cancer treatment: surgery, chemotherapy, radiation therapy and the newest pillar, immunotherapy. In this review we provide an overview of notable advances of nanomedicine in improving drug delivery, radiation therapy and immunotherapy. Potential barriers in the translation of nanomedicine from bench to bedside as well as strategies to overcome these barriers are also discussed. Promising preclinical findings highlight the translational and clinical potential of integrating nanotechnology approaches into cancer care.
在过去二十年中，纳米技术对基础和临床癌症研究产生了重大影响。由于多学科的进步，癌症纳米技术旨在解决当前癌症治疗模式中存在的问题，最终目标是提高治疗效果、延长患者生存期并减少毒副作用。纳米医学在癌症靶向治疗和疗法中的应用潜力不断增长，目前已用于推进癌症治疗的四大传统支柱：手术、化疗、放疗以及最新的支柱——免疫疗法。在本综述中，我们概述了纳米医学在改善药物递送、放疗和免疫疗法方面的显著进展。还讨论了纳米医学从实验室到临床应用过程中存在的潜在障碍以及克服这些障碍的策略。有前景的临床前研究结果凸显了将纳米技术方法整合到癌症治疗中的转化和临床潜力。
