Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406040, Taiwan.
Research Center for Cancer Biology, China Medical University, Taichung 406040, Taiwan.
Int J Mol Sci. 2023 Apr 1;24(7):6600. doi: 10.3390/ijms24076600.
Cancer immunotherapy has made breakthrough progress in cancer treatment. However, only a subset of patients benefits from immunotherapy. Given their unique structure, composition, and interactions with the immune system, carbon nanomaterials have recently attracted tremendous interest in their roles as modulators of antitumor immunity. Here, we focused on the latest advances in the immunological effects of carbon nanomaterials. We also reviewed the current preclinical applications of these materials in cancer therapy. Finally, we discussed the challenges to be overcome before the full potential of carbon nanomaterials can be utilized in cancer therapies to ultimately improve patient outcomes.
癌症免疫疗法在癌症治疗方面取得了突破性进展。然而，只有一部分患者受益于免疫疗法。鉴于其独特的结构、组成和与免疫系统的相互作用，碳纳米材料作为抗肿瘤免疫调节剂的作用最近引起了极大的关注。在这里，我们重点介绍了碳纳米材料免疫效应的最新进展。我们还回顾了这些材料在癌症治疗中的当前临床前应用。最后，我们讨论了在充分利用碳纳米材料治疗癌症以最终改善患者预后之前需要克服的挑战。
