Zhao Bin, Chen Sa, Hong Ye, Jia Liangliang, Zhou Ying, He Xinyu, Wang Ying, Tian Zhongmin, Yang Zhe, Gao Di
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
Department of Epidemiology, Shaanxi Provincial Cancer Hospital, Xi'an 710061, China.
Pharmaceutics. 2022 Jul 21;14(7):1522. doi: 10.3390/pharmaceutics14071522.
The conventional cancer therapeutic modalities include surgery, chemotherapy and radiotherapy. Although immunotherapy and targeted therapy are also widely used in cancer treatment, chemotherapy remains the cornerstone of tumor treatment. With the rapid development of nanotechnology, nanomedicine is believed to be an emerging field to further improve the efficacy of chemotherapy. Until now, there are more than 17 kinds of nanomedicine for cancer therapy approved globally. Thereinto, conjugated nanomedicine, as an important type of nanomedicine, can not only possess the targeted delivery of chemotherapeutics with great precision but also achieve controlled drug release to avoid adverse effects. Meanwhile, conjugated nanomedicine provides the platform for combining several different therapeutic approaches (chemotherapy, photothermal therapy, photodynamic therapy, thermodynamic therapy, immunotherapy, etc.) with the purpose of achieving synergistic effects during cancer treatment. Therefore, this review focuses on conjugated nanomedicine and its various applications in synergistic chemotherapy. Additionally, the further perspectives and challenges of the conjugated nanomedicine are also addressed, which clarifies the design direction of a new generation of conjugated nanomedicine and facilitates the translation of them from the bench to the bedside.
传统的癌症治疗方式包括手术、化疗和放疗。尽管免疫疗法和靶向疗法也广泛应用于癌症治疗，但化疗仍然是肿瘤治疗的基石。随着纳米技术的快速发展，纳米医学被认为是一个能够进一步提高化疗疗效的新兴领域。截至目前，全球已有17种以上用于癌症治疗的纳米药物获批。其中，共轭纳米药物作为纳米药物的一种重要类型，不仅能够实现化疗药物的高精度靶向递送，还能实现药物的控释以避免不良反应。同时，共轭纳米药物为结合多种不同治疗方法（化疗、光热疗法、光动力疗法、热动力疗法、免疫疗法等）提供了平台，目的是在癌症治疗过程中实现协同效应。因此，本综述聚焦于共轭纳米药物及其在协同化疗中的各种应用。此外，还讨论了共轭纳米药物的进一步前景和挑战，这阐明了新一代共轭纳米药物的设计方向，并促进其从实验室到临床的转化。
