Dakum Patrick, Avong Yohanna Kambai, Odutola Michael Kolawole, Okuma James, Kayode Gbenga Ayodele, Nta Iboro Ekpo, Ndembi Nicaise, Mensah Charles, Khamofu Hadiza, Okonkwo Prosper, Okpanachi John Oko, Ezeanolue Echezona
Institute of Human Virology, Abuja, Nigeria.
FHI360, Abuja, Nigeria.
BMC Public Health. 2020 Nov 26;20(1):1797. doi: 10.1186/s12889-020-09833-9.
The Nigerian HIV Geriatric Cohort (NHGC) is a longitudinal cohort setup to learn how elderly people living with HIV (EPLHIV) in Nigeria fare, despite not being prioritized by the national treatment program, and to deepen knowledge for their differentiated care and achieve better outcomes. In this paper, we describe data collected on sociodemographic and clinical data from EPLHIV from the inception of Nigeria's national HIV program to 2018.
Patient-level data spanning the period 2004 to 2018, obtained from comprehensive HIV treatment hospitals, that are supported by four major PEPFAR-implementing partners in Nigeria were used. These 4 entities collaborated as member organizations of the Nigeria Implementation Science Alliance. We defined elderly as those aged 50 years and above. From deidentified treatment records, demographic and clinical data of EPLHIV ≥50-year-old at ART initiation during the review period was extracted, merged into a single REDcap® database, and described using STATA 13.
A total of 101,652 EPLHIV were analysed. Women accounted for 53,608 (53%), 51,037 (71%) of EPLHIV identified as married and 33,446 (51%) unemployed. Median age was 57.1 years (IQR 52-60 years) with a median duration on ART treatment of 4.1 years (IQR 1.7-7.1 years). ART profile showed that 97,586 (96%) were on 1st-line and 66,125 (65%) were on TDF-based regimens. Median body mass index (BMI) was 22.2 kg/m (IQR 19.5-25.4 kg/m) with 43,012 (55%), 15,081 (19%) and 6803 (9%) showing normal (BMI 18.5 - < 25 kg/m), overweight (BMI 25 - < 30 kg/m) and obese (BMI ≥30 kg/m) ranges respectively. Prevalence of hypertension (systolic-BP > 140 mmHg or diastolic-BP > 90 mmHg) was 16,201 (21%). EPLHIV median CD4 count was 381 cells/μL (IQR 212-577 cells/μL) and 26,687 (82%) had a viral load result showing < 1000copies/ml within one year of their last visit. As for outcomes at their last visit, 62,821 (62%) were on active-in-treatment, 28,463 (28%) were lost-to-follow-up, 6912 (7%) died and 2456 (3%) had stopped or transferred out. Poor population death records and aversion to autopsies makes it almost impossible to estimate AIDS-related deaths.
This cohort describes the clinical and non-clinical profile of EPLHIV in Nigeria. We are following up the cohort to design and implement intervention programs, develop prognostic models to achieve better care outcomes for EPLHIV. This cohort would provide vital information for stakeholders in HIV prevention, care and treatment to understand the characteristics of EPLHIV.
尼日利亚艾滋病毒老年队列（NHGC）是一个纵向队列，旨在了解尼日利亚感染艾滋病毒的老年人（EPLHIV）的情况，尽管他们未被国家治疗计划列为优先对象，并深化对其差异化护理的认识，以实现更好的治疗效果。在本文中，我们描述了从尼日利亚国家艾滋病毒计划启动到2018年期间收集的EPLHIV的社会人口统计学和临床数据。
使用从尼日利亚四个主要的总统紧急救援计划（PEPFAR）实施伙伴支持的综合艾滋病毒治疗医院获得的2004年至2018年期间的患者层面数据。这4个实体作为尼日利亚实施科学联盟的成员组织进行合作。我们将老年人定义为年龄在50岁及以上的人。从去识别化的治疗记录中，提取了审查期间开始接受抗逆转录病毒治疗（ART）时年龄≥50岁的EPLHIV的人口统计学和临床数据，合并到一个单一的REDCap®数据库中，并使用STATA 13进行描述。
共分析了101,652例EPLHIV。女性占53,608例（53%），在已识别的已婚EPLHIV中占51,037例（71%），失业者占33,446例（51%）。中位年龄为57.1岁（四分位间距52 - 60岁），ART治疗的中位持续时间为4.1年（四分位间距1.7 - 7.1年）。ART治疗情况显示，97,586例（96%）接受一线治疗，66,125例（65%）接受基于替诺福韦二吡呋酯（TDF）的治疗方案。中位体重指数（BMI）为22.2kg/m（四分位间距19.5 - 25.4kg/m），其中43,012例（55%）、15,081例（19%）和6803例（9%）分别显示体重正常（BMI 18.
