Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea.
Department of Emergency Medicine, Chungnam National University Hospital, Daejeon, South Korea; Department of Emergency Medicine, College of medicine, Chungnam National University, Daejeon, South Korea.
Am J Emerg Med. 2021 Feb;40:184-187. doi: 10.1016/j.ajem.2020.11.005. Epub 2020 Nov 7.
Aconitine is well-known for its potential analgesic, anti-inflammatory, and circulation promoting effects and has been widely used as a folk medicine in South Korea. Owing to its extremely toxic nature and relatively low safety margin, intoxication is sometimes fatal. The toxic compound mainly affects the central nervous system, heart, and muscle, resulting in cardiovascular complications.
To determine the exact relationship between blood concentration of aconitine and clinical manifestation.
The National Forensic Service (NFS) was commissioned to assist in a quantitative analysis of highly toxic aconitine and corresponding blood concentrations by analyzing the body fluids of three patients who were suspected of aconitine poisoning.
Aconitine blood values tested by the NFS showed that patients with a blood concentration below a certain level developed symptoms slowly and showed a high severity of clinical manifestation. There was no correlation between blood concentration and symptoms or ECG results.
In case of suspected aconitine poisoning, an emergency care department should be visited, even with symptomatic improvement, and the patient should be monitored for at least 24 h, depending on the level of recovery and changes in ECG results.
乌头碱具有潜在的镇痛、抗炎和促进循环作用，在韩国被广泛用作民间药物。由于其毒性极强，安全边际相对较低，中毒有时是致命的。毒性化合物主要影响中枢神经系统、心脏和肌肉，导致心血管并发症。
确定乌头碱血浓度与临床表现的确切关系。
国家法医服务局（NFS）受委托通过分析三名疑似乌头碱中毒患者的体液，协助对剧毒乌头碱和相应的血浓度进行定量分析。
NFS 测试的乌头碱血值表明，血浓度低于一定水平的患者症状发展缓慢，临床表现严重程度高。血浓度与症状或 ECG 结果之间没有相关性。
疑似乌头碱中毒时，即使症状改善，也应到急救部门就诊，并根据恢复程度和 ECG 结果的变化，至少监测 24 小时。
