Hollister Brittany M, Yaremych Haley E, Goldring Megan R, Persky Susan
Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Department of Psychology, Columbia University, New York, NY, USA.
Environ Epigenet. 2019 Nov 25;5(4):dvz021. doi: 10.1093/eep/dvz021. eCollection 2019 Oct.
Advances in our understanding of epigenetics present new opportunities to improve children's health through the counseling of parents about epigenetics concepts. However, it is important to first evaluate how parents respond to this type of information and determine the consequences of educating parents about epigenetics. We have taken an initial step toward this goal by assessing parental responses to an epigenetics learning module. Parents ( = 190, 126 mothers) responded to pre- and post-module survey questions. Prior to the module, parents reported that mothers' lifestyles prior to conception were more important for children's health than fathers' lifestyles prior to conception ( = 4.49, df = 316.5, < 0.0001). However, after the module, there was no difference between ratings of the importance of mothers' and fathers' preconception lifestyles ( = 1.18, df = 319.8, = NS). Furthermore, after viewing the module, parents increased their ratings of the importance of both mothers' ( = -5.65, df = 294.8, < 0.0001) and father's ( = -9.01, df = 287.2, < 0.0001) preconception lifestyles for child health. After viewing the module, most parents reported feelings of guilt and negativity regarding epigenetics (78 and 55%, respectively). When compared with lean parents, parents with overweight more often reported feelings of guilt ( =10.27, = 0.001). This work represents an important first step in evaluating parental responses to epigenetics concepts.
我们对表观遗传学理解的进展为通过向父母传授表观遗传学概念来改善儿童健康带来了新机遇。然而,首先评估父母对这类信息的反应并确定向父母传授表观遗传学知识的后果非常重要。我们通过评估父母对一个表观遗传学学习模块的反应,朝着这个目标迈出了第一步。父母((n = 190),其中126位是母亲)回答了模块前后的调查问卷问题。在模块之前,父母报告说,受孕前母亲的生活方式对孩子健康比受孕前父亲的生活方式更重要((t = 4.49),自由度(df = 316.5),(p < 0.0001))。然而,在模块之后,对母亲和父亲受孕前生活方式重要性的评分没有差异((t = 1.18),自由度(df = 319.8),(p = 无显著差异))。此外,观看模块后,父母提高了对母亲((t = -5.65),自由度(df = 294.8),(p < 0.0001))和父亲((t = -9.01),自由度(df = 287.2),(p < 0.0001))受孕前生活方式对孩子健康重要性的评分。观看模块后,大多数父母报告了对表观遗传学感到内疚和消极的情绪(分别为78%和55%)。与体重正常的父母相比,超重的父母更常报告有内疚感((t = 10.27),(p = 0.001))。这项工作是评估父母对表观遗传学概念反应的重要第一步。