Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.
Department of Computing Science, University of Alberta, Edmonton, AB T6G 2E8, Canada.
Nucleic Acids Res. 2021 Jan 8;49(D1):D1259-D1267. doi: 10.1093/nar/gkaa1067.
MarkerDB is a freely available electronic database that attempts to consolidate information on all known clinical and a selected set of pre-clinical molecular biomarkers into a single resource. The database includes four major types of molecular biomarkers (chemical, protein, DNA [genetic] and karyotypic) and four biomarker categories (diagnostic, predictive, prognostic and exposure). MarkerDB provides information such as: biomarker names and synonyms, associated conditions or pathologies, detailed disease descriptions, detailed biomarker descriptions, biomarker specificity, sensitivity and ROC curves, standard reference values (for protein and chemical markers), variants (for SNP or genetic markers), sequence information (for genetic and protein markers), molecular structures (for protein and chemical markers), tissue or biofluid sources (for protein and chemical markers), chromosomal location and structure (for genetic and karyotype markers), clinical approval status and relevant literature references. Users can browse the data by conditions, condition categories, biomarker types, biomarker categories or search by sequence similarity through the advanced search function. Currently, the database contains 142 protein biomarkers, 1089 chemical biomarkers, 154 karyotype biomarkers and 26 374 genetic markers. These are categorized into 25 560 diagnostic biomarkers, 102 prognostic biomarkers, 265 exposure biomarkers and 6746 predictive biomarkers or biomarker panels. Collectively, these markers can be used to detect, monitor or predict 670 specific human conditions which are grouped into 27 broad condition categories. MarkerDB is available at https://markerdb.ca.
MarkerDB 是一个免费的电子数据库，旨在将所有已知的临床和精选的一组临床前分子生物标志物信息整合到一个单一的资源中。该数据库包括四大类分子生物标志物（化学、蛋白质、DNA[遗传]和核型）和四类生物标志物类别（诊断、预测、预后和暴露）。MarkerDB 提供了如下信息：生物标志物名称和同义词、相关病症或病理学、详细的疾病描述、详细的生物标志物描述、生物标志物特异性、敏感性和 ROC 曲线、标准参考值（针对蛋白质和化学标志物）、变体（针对 SNP 或遗传标志物）、序列信息（针对遗传和蛋白质标志物）、分子结构（针对蛋白质和化学标志物）、组织或生物流体来源（针对蛋白质和化学标志物）、染色体位置和结构（针对遗传和核型标志物）、临床批准状态和相关文献参考。用户可以通过病症、病症类别、生物标志物类型、生物标志物类别浏览数据，也可以通过高级搜索功能按序列相似性进行搜索。目前，该数据库包含 142 个蛋白质生物标志物、1089 个化学生物标志物、154 个核型生物标志物和 26374 个遗传标志物。这些标志物被分为 25560 个诊断生物标志物、102 个预后生物标志物、265 个暴露生物标志物和 6746 个预测生物标志物或生物标志物组合。这些标志物可用于检测、监测或预测 670 种特定的人类病症，这些病症被分为 27 个广泛的病症类别。MarkerDB 可在 https://markerdb.ca 上获取。
