Department of Obstetrics and Gynecology, Maison Blanche Hospital, Reims Champagne-Ardenne University, 45, Cognacq-Jay, 51100, Reims, France.
Department of Obstetrics and Gynecology, Maison Blanche Hospital, Reims Champagne-Ardenne University, 45, Cognacq-Jay, 51100, Reims, France.
J Gynecol Obstet Hum Reprod. 2021 Sep;50(7):102001. doi: 10.1016/j.jogoh.2020.102001. Epub 2020 Nov 24.
To evaluate the knowledge of pregnant women and provide information about Down syndrome (DS) screening, including non-invasive prenatal testing (NIPT).
A prospective unicenter study of pregnant women recruited during their first trimester foetal ultrasound was carried out. Single pregnancies from 11 to 17 + 6 weeks of amenorrhoea (SA) without a history of DS were included. "Pre" and "post" questionnaire were fulfilled before and after the consultation. Patient characteristics, prior information, information provided during the consultation, and patient satisfaction were also analysed.
A total of 273 were included in the study, and 147 completed surveys (pre and post) were examined. In pre-consultation, 82 % of women know that integrated screening includes maternal serum markers and nuchal translucency (n = 103). Concerning NIPT for DS, 8% (n = 11) of women declare having been informed before the ultrasound. A minority of patients know modalities of reimbursement (n = 33, 26 %) and invasive sampling is mandatory for diagnosis when NIPT is positive (n = 37, 28 %). Significant improvement in right answers was obtained for three questions: "nuchal translucency is included in the combined screening test for DS" (p = 0,007); "blood serum markers is included in the combined screening for DS" (p = 0,009) and advanced maternal age increases risk for DS" (p = 0,004). Total score in the post questionnaire was significantly higher than the "pre" consultation questionnaire (14,7 ± 2.8 versus 14,1 ± 2.9; p = 0.01).
Patients show a high level of knowledge on screening strategies for DS in pre-consultation. They benefit from the consultation on global knowledge, NIPT, and ultrasound notions.
评估孕妇的知识水平，并提供有关唐氏综合征（DS）筛查的信息，包括非侵入性产前检测（NIPT）。
这是一项在首次胎儿超声检查期间招募的孕妇的前瞻性单中心研究。纳入无 DS 病史、停经 11 至 17+6 周的单胎妊娠。在咨询前后填写“预”和“后”调查问卷。还分析了患者特征、先前信息、咨询期间提供的信息以及患者满意度。
共有 273 例患者纳入研究，其中 147 例完成了预、后调查问卷。在咨询前，82%的女性（n=103）知道综合筛查包括母体血清标志物和颈项透明层（nuchal translucency，NT）。关于用于 DS 的 NIPT，8%（n=11）的女性在超声检查前被告知过。少数患者知道报销方式（n=33，26%），当 NIPT 阳性时，侵入性取样是诊断的必要条件（n=37，28%）。有三个问题的正确答案比例显著提高：“颈项透明层包含在用于 DS 的联合筛查试验中”（p=0.007）；“血清标志物包含在用于 DS 的联合筛查中”（p=0.009）；以及“高龄产妇增加 DS 的风险”（p=0.004）。后调查问卷的总分明显高于预调查问卷（14.7±2.8 与 14.1±2.9；p=0.01）。
患者在咨询前对 DS 筛查策略的知识水平较高。他们从关于总体知识、NIPT 和超声概念的咨询中受益。
