Di Padova C, Worner T M, Lieber C S
Alcohol Research and Treatment Center, Veterans Administration Medical Center, Bronx, New York 10468.
Alcohol Clin Exp Res. 1987 Dec;11(6):559-61. doi: 10.1111/j.1530-0277.1987.tb00174.x.
Following an acute dose of alcohol (0.15 g/kg intravenously), blood levels of acetaldehyde were significantly higher in nonabstinent alcoholics than in controls. After 2 weeks of abstinence, this blood acetaldehyde response significantly decreased in alcoholics and the acetaldehyde returned towards levels comparable to those observed in nonalcoholics. These results suggest that elevated blood acetaldehyde levels in the alcoholics are secondary to the chronic alcohol consumption rather than reflecting a primary preexisting defect.
静脉注射急性剂量酒精（0.15克/千克）后，未戒酒的酗酒者血液中的乙醛水平显著高于对照组。戒酒2周后，酗酒者的这种血液乙醛反应显著降低，乙醛水平恢复到与非酗酒者相当的水平。这些结果表明，酗酒者血液中乙醛水平升高是长期饮酒的结果，而非反映原发性的先天缺陷。
