人类癌症发病机制中的 Epstein-Barr 病毒 microRNAs。

Epstein-Barr virus microRNAs in the pathogenesis of human cancers.

机构信息

São Paulo State University (UNESP), Medical School of Botucatu Av. Prof. Mário Rubens Guimarães Montenegro, s/n. CEP 18618-687, Botucatu, SP, Brazil; São Paulo State University (UNESP), Institute of Biotechnology (IBTEC) Alameda das Tecomarias, s/n. CEP 18607-440, Botucatu, SP, Brazil.

São Paulo State University (UNESP), Institute of Biosciences of Botucatu R. Prof. Dr. Antônio Celso Wagner Zanin, 250. CEP 18618-689, Botucatu, SP, Brazil; São Paulo State University (UNESP), Institute of Biotechnology (IBTEC) Alameda das Tecomarias, s/n. CEP 18607-440, Botucatu, SP, Brazil.

出版信息

Cancer Lett. 2021 Feb 28;499:14-23. doi: 10.1016/j.canlet.2020.11.019. Epub 2020 Nov 25.

DOI:10.1016/j.canlet.2020.11.019

PMID:33248209

Abstract

The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human oncoviruses to encode viral microRNAs (miRNAs), and these molecules were found to interact with viral and host targets. EBV miRNAs modulate biological processes that are critical for carcinogenesis, contributing to cell transformation and tumor progression of EBV-associated cancers. Herein we review and discuss EBV miRNAs as modulators of viral biology and carcinogenesis, as well as their usefulness as putative markers to monitor the onset, progression, and recurrence of cancers associated with the EBV infection.

摘要

EB 病毒（EBV）是一种与多种人类癌症有关的γ疱疹病毒，特别是地方性伯基特淋巴瘤和鼻咽癌。2004 年，EBV 被描述为已知的第一个能够编码病毒 microRNAs（miRNAs）的人类致癌病毒之一，并且这些分子被发现与病毒和宿主靶标相互作用。EBV miRNAs 调节对致癌作用至关重要的生物学过程，有助于 EBV 相关癌症的细胞转化和肿瘤进展。在此，我们回顾和讨论 EBV miRNAs 作为病毒生物学和致癌作用的调节剂，以及它们作为监测与 EBV 感染相关癌症的发生、进展和复发的潜在标志物的有用性。