Zhang L, Lu J R, Waigh T A
Biological Physics, Department of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Biological Physics, Department of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Adv Colloid Interface Sci. 2021 Jan;287:102319. doi: 10.1016/j.cis.2020.102319. Epub 2020 Nov 14.
Biologically inspired peptide- and protein-based materials are at the forefront of organic bioelectronics research due to their inherent conduction properties and excellent biocompatibility. Peptides have the advantages of structural simplicity and ease of synthesis providing credible prospects for mass production, whereas naturally expressed proteins offer inspiration with many examples of high performance evolutionary optimised bioelectronics properties. We review recent advances in the fundamental conduction mechanisms, experimental techniques and exemplar applications for the bioelectronics of self-assembling peptides and proteins. Diverse charge transfer processes, such as tunnelling, hopping and coupled transfer, are found in naturally occurring biological systems with peptides and proteins as the predominant building blocks to enable conduction in biology. Both theory and experiments allow detailed investigation of bioelectronic properties in order to design functionalized peptide- and protein-based biomaterials, e.g. to create biocompatible aqueous electrodes. We also highlight the design of bioelectronics devices based on peptides/proteins including field-effect transistors, piezoelectric energy harvesters and optoelectronics.
受生物启发的基于肽和蛋白质的材料，因其固有的传导特性和出色的生物相容性，处于有机生物电子学研究的前沿。肽具有结构简单和易于合成的优点，为大规模生产提供了可靠的前景，而天然表达的蛋白质则通过许多具有高性能进化优化生物电子特性的例子提供了灵感。我们综述了自组装肽和蛋白质生物电子学在基本传导机制、实验技术和典型应用方面的最新进展。在以肽和蛋白质为主要构建块的天然生物系统中，发现了多种电荷转移过程，如隧穿、跳跃和耦合转移，以实现生物体内的传导。理论和实验都允许对生物电子特性进行详细研究，以便设计功能化的基于肽和蛋白质的生物材料，例如制造生物相容性水性电极。我们还强调了基于肽/蛋白质的生物电子器件的设计，包括场效应晶体管、压电能量收集器和光电器件。
