College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Faculty of Veterinary & Animal Sciences, Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Poult Sci. 2020 Dec;99(12):6422-6433. doi: 10.1016/j.psj.2020.08.055. Epub 2020 Sep 8.
Tibial dyschondroplasia (TD) is a metabolic tibiotarsal bone disease in rapidly growing birds throughout the world, which is characterized by gait disorders, reduced growth, and in an unrecoverable lameness in many cases. The short production cycle in chickens, long metabolism cycle in most of the drugs with the severe drug residue, and high treatment cost severely restrict the enthusiasm for the treatment of TD. Traditional Chinese medicine (TCM) has been used for the prevention, treatment, and cure of avian bone diseases. Previously, a couple of traditional Chinese medicines has been reported being useful in treating TD. This review will discuss the TCM used in TD and the alternative TCM to treat TD. Selecting a TCM approach and its pharmacologic effects on TD chickens mainly focused on the differentiation, proliferation, and apoptosis of chondrocytes, angiogenesis, matrix metabolism, oxidative damage, cytokines, and calcification of cartilage in tibia.
胫骨软骨发育不良（TD）是一种发生在全世界快速生长鸟类中的代谢性胫跗骨疾病，其特征为步态障碍、生长减缓，在许多情况下导致不可恢复的跛行。鸡的生产周期短，大多数药物的代谢周期长，且药物残留严重，治疗成本高，严重限制了对 TD 治疗的积极性。中医疗法已被用于预防、治疗和治愈禽骨疾病。以前，已有一些中药被报道对治疗 TD 有效。本综述将讨论用于 TD 的中医疗法以及替代治疗 TD 的中医疗法。选择中医疗法及其对 TD 鸡的药理作用主要集中在软骨细胞的分化、增殖和凋亡、血管生成、基质代谢、氧化损伤、细胞因子和软骨钙化上。
