细胞穿透肽：用于癌症药物和基因共递送的多功能载体。
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer.
机构信息
Center for Pharmaceutical Biotechnology and Nanomedicines, Northeastern University, Boston, MA 02115, USA; Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
Center for Pharmaceutical Biotechnology and Nanomedicines, Northeastern University, Boston, MA 02115, USA; Departments of Lipids and Liposomes, Faculty of Biotechnology, University of Wroclaw, 50-383 Wroclaw, Poland.
出版信息
J Control Release. 2021 Feb 10;330:1220-1228. doi: 10.1016/j.jconrel.2020.11.028. Epub 2020 Nov 25.
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell penetrating peptides (CPP) have the ability to rapidly internalize across biological membranes. CPP have been effective for delivery of various chemotherapeutic agents used to combat cancer. CPP can enhance delivery of drugs to a targeted site when combined with tumor targeting peptides. CPP can be linked with various cargos like nanoparticles, micelles and liposomes to deliver drugs and genes to the cancer cell. Here, we focus on CPP mediated delivery of drugs to the tumor sites, delivery of genes (siRNA,pDNA) and co-delivery of drugs and genes to combat drug resistance.
生物屏障阻碍了药物和基因有效递送至靶向部位。细胞穿透肽 (CPP) 具有快速跨生物膜内化的能力。CPP 已被证明可有效递送至用于治疗癌症的各种化疗药物。CPP 与肿瘤靶向肽结合时，可增强药物递送至靶向部位的效果。CPP 可以与各种载体（如纳米颗粒、胶束和脂质体）结合，将药物和基因递送至癌细胞。在这里，我们专注于 CPP 介导的药物递送至肿瘤部位、基因（siRNA、pDNA）的递送以及药物和基因的共递送至对抗耐药性。
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