Lacarrubba Francesco, Nasca Maria Rita, Puglisi Davide Francesco, Micali Giuseppe
Dermatology Clinic, University of Catania, Italy.
Int J Clin Pract. 2020 Dec;74 Suppl 187:e13626. doi: 10.1111/ijcp.13626.
Urea is a hygroscopic molecule that, because of its moisturising properties, is topically used for the treatment of skin dryness at concentrations ranging from 2% to 12% in different formulations. Based on existing literature, low-concentration urea-containing products are effective in the treatment and/or prevention of xerosis in some skin disorders such as ichthyosis, atopic dermatitis and psoriasis, or unrelated to specific skin diseases. Generally, urea formulations at low concentration are well-tolerated and suited for the treatment of large skin areas, once or twice daily, even for a long period of time. At low concentrations stinging and burning sensation is rare and transient, whit no reported sensitisation despite its widespread use.
尿素是一种吸湿分子，由于其保湿特性，在不同配方中以2%至12%的浓度局部用于治疗皮肤干燥。根据现有文献，低浓度含尿素产品在治疗和/或预防某些皮肤疾病（如鱼鳞病、特应性皮炎和银屑病）的皮肤干燥或与特定皮肤疾病无关的皮肤干燥方面是有效的。一般来说，低浓度尿素制剂耐受性良好，适合大面积皮肤治疗，每天一次或两次，甚至可长期使用。低浓度时，刺痛和烧灼感很少见且短暂，尽管广泛使用，但未报告有过敏反应。
