10%尿素乳膏治疗老年性皮肤干燥症：临床与仪器评估
10% urea cream in senile xerosis: Clinical and instrumental evaluation.
作者信息
Lacarrubba Francesco, Verzì Anna Elisa, Dinotta Franco, Micali Giuseppe
机构信息
Dermatology Clinic, University of Catania, Catania, Italy.
出版信息
J Cosmet Dermatol. 2021 Apr;20 Suppl 1(Suppl 1):5-8. doi: 10.1111/jocd.14093.
BACKGROUND
Moisturizers represent the mainstay of treatment of xerosis and related pruritus in elderly patients.
AIM
In this study, we evaluated the efficacy and tolerability of a 10% urea cream in patients with senile xerosis.
METHODS
Twenty patients affected by moderate-to-severe xerosis of the upper or lower extremities were enrolled and instructed to apply twice daily for 2 weeks a cream containing 10% urea. Evaluation was performed at baseline and after 7 and 14 days by: clinical examination, itch assessment using a Visual Analogue Scale (VAS), and dermoscopy.
RESULTS
After 7 and 14 days of treatment, the tested urea-based cream resulted in a significant, progressive clinical improvement of xerosis and related pruritus in all patients. The clinical results were supported by dermoscopy that showed the reduction/disappearance of scales. The cream, that had a good cosmetological acceptability, was well tolerated with no report of stinging or burning and/or other side effects.
CONCLUSIONS
Urea confirms to represent a key molecule for the treatment of senile xerosis.
背景
保湿剂是老年患者皮肤干燥症及相关瘙痒症治疗的主要手段。
目的
在本研究中，我们评估了10%尿素乳膏治疗老年皮肤干燥症患者的疗效和耐受性。
方法
招募了20例患有中重度上下肢皮肤干燥症的患者，并指导他们每天两次涂抹含10%尿素的乳膏，持续2周。在基线以及7天和14天后通过以下方式进行评估：临床检查、使用视觉模拟量表（VAS）评估瘙痒程度以及皮肤镜检查。
结果
治疗7天和14天后，所测试的含尿素乳膏使所有患者的皮肤干燥症及相关瘙痒症在临床上有显著的、逐渐的改善。皮肤镜检查结果支持了临床结果，显示鳞屑减少/消失。该乳膏具有良好的美容可接受性，耐受性良好，未报告有刺痛、烧灼感和/或其他副作用。
结论
尿素被证实是治疗老年皮肤干燥症的关键分子。
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