Lodén M, Andersson A C, Andersson C, Frödin T, Oman H, Lindberg M
ACO Hud AB, Stockholm, Sweden.
Skin Res Technol. 2001 Nov;7(4):209-13.
BACKGROUND/AIMS: Moisturising creams are useful treatment adjuncts in inflammatory dermatoses and have beneficial effects in the treatment of dry, scaly skin. The effects on dryness and skin permeability of a new moisturising cream with 20% glycerine was compared with its placebo and with a medicinally authorised cream with 4% urea (combined with 4% sodium chloride) in the treatment of dry skin.
Patients (n=109) with atopic dermatitis were treated for 30 days with a moisturiser in a randomised, parallel and double-blind fashion. Transepidermal water loss (TEWL) and skin capacitance were assessed instrumentally, and changes in the dryness of the skin were assessed by the dermatologist.
No difference in TEWL was found between glycerine treatment and its placebo, whereas a lower value was found in the urea-treated area compared to the glycerine-treated area. No difference in skin capacitance was found. The clinical assessment of dryness showed urea to be superior to glycerine in treating the condition.
Moisturising creams are different, not only with respect to composition but also with respect to their influence on skin as a barrier to water in patients with atopic dermatitis.
背景/目的：保湿霜是炎症性皮肤病的有用治疗辅助剂，对干性、鳞屑性皮肤的治疗具有有益效果。将一种含20%甘油的新型保湿霜与其安慰剂以及一种含4%尿素（与4%氯化钠合用）的药用授权霜在治疗干性皮肤方面对皮肤干燥度和通透性的影响进行了比较。
109例特应性皮炎患者以随机、平行和双盲方式用一种保湿剂治疗30天。通过仪器评估经表皮水分流失（TEWL）和皮肤电容，并由皮肤科医生评估皮肤干燥度的变化。
甘油治疗组与其安慰剂组之间的TEWL无差异，而与甘油治疗区域相比，尿素治疗区域的TEWL值较低。皮肤电容方面未发现差异。干燥度的临床评估显示，尿素在治疗该病症方面优于甘油。
保湿霜不仅在成分方面不同，而且在对特应性皮炎患者皮肤作为水屏障的影响方面也不同。
