International Renal Research Institute, S. Bortolo Hospital, Vicenza, Italy.
Department of Research, Innovation and Brand Reputation, ASST Papa Giovanni XXIII, Bergamo, Italy.
Heart Fail Clin. 2019 Oct;15(4):463-476. doi: 10.1016/j.hfc.2019.05.002. Epub 2019 Jul 5.
Patients with acute or chronic decompensated heart failure (ADHF) present with various degrees of heart and kidney dysfunction characterizing cardiorenal syndrome (CRS). CRS can be generally defined as a pathophysiologic disorder of the heart and kidneys whereby acute or chronic dysfunction of 1 organ may induce acute or chronic dysfunction of the other. ADHF is a challenge in the management of heart failure. This review provides an overview the pathophysiology of type 1 CRS together with new approaches to treatment in patients with heart failure with worsening renal function or acute kidney disease.
患有急性或慢性失代偿性心力衰竭（ADHF）的患者表现出不同程度的心脏和肾脏功能障碍，这些特征构成了心肾综合征（CRS）。CRS 通常可以定义为心脏和肾脏的一种病理生理紊乱，其中 1 个器官的急性或慢性功能障碍可能导致另一个器官的急性或慢性功能障碍。ADHF 是心力衰竭管理中的一个挑战。这篇综述提供了 1 型 CRS 的病理生理学概述，以及在心力衰竭患者中出现肾功能恶化或急性肾损伤时的新治疗方法。
