Melander A, Kahlmeter G, Kamme C, Ursing B
Eur J Clin Pharmacol. 1977 Aug 17;12(1):69-72. doi: 10.1007/BF00561408.
The possible influence of food intake on the bioavailability of metronidazole was examined in ten health volunteers by administration of a single dose of metronidazole on an empty stomach, and with a standardized breakfast. Food intake did not significantly alter the bioavailability of metronidazole. The interindividual variation in bioavailability appeared to be slight. In nine patients with Crohn's disease, the absorption of metronidazole appeared to be reduced and to be more variable than in healthy subjects. In both groups there was a clear relationship between the amount absorbed and dose/kg body weight. Thus, from the pharmacokinetic point of view, metronidazole can safely be given either with or between meals. The dose should be related to body weight.
通过让十名健康志愿者在空腹状态下以及搭配标准化早餐服用单剂量甲硝唑，研究了食物摄入对甲硝唑生物利用度的可能影响。食物摄入并未显著改变甲硝唑的生物利用度。生物利用度的个体间差异似乎较小。在九名克罗恩病患者中，甲硝唑的吸收似乎减少，且比健康受试者更具变异性。在两组中，吸收量与每千克体重的剂量之间均存在明确的关系。因此，从药代动力学角度来看，甲硝唑在进餐时或两餐之间服用均可安全给药。剂量应与体重相关。
