Taïbi Khaled, Abderrahim Leila Ait, Ferhat Karima, Betta Soria, Taïbi Fadhila, Bouraada Fatiha, Boussaid Mohamed
Faculty of Life and Natural Sciences, University of Tiaret, 14000, Algeria.
Instituto de Biología Molecular y Celular de Plantas (IBMCP), Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas, Camino de Vera s/n, 46022 Valencia, Spain.
Saudi Pharm J. 2020 Nov;28(11):1451-1465. doi: 10.1016/j.jsps.2020.09.011. Epub 2020 Sep 21.
Traditional and complementary medicine constitutes an important, and often underestimated, source of healthcare for multiple diseases including cancer. However, little is known about the ethnomedical knowledge and practices in Northern Africa. The main objective of this study is to identify and analyze the variety of natural products used in Algerian ethnopharmacology for cancer therapy. For this purpose, semi-structured interviews with 225 traditional healers, herbalists and practitioners were realized in twelve locations in Algeria throughout field studies performed from June 2015 to July 2019. Interviews covered popular and vernacular names of the natural product, mode of use and administration, dose, period of treatment, toxicity and side effects among other data. The obtained results reveal the use of 113 medicinal plants (belonging to 53 families and 104 genera), 10 animal species and various products and by-products from different origins such as honey, olive oil, thorns, urine, milk, animal fat and the alkaline water of Zamzam. Basing on the frequency of citation (FC), use reports (UR) and use value (UV), the most used natural products for cancer treatment are honey (FC = 181, UR = 194, UV = 0.65), L. (FC = 131, UR = 152, UV = 0.54), L. (FC = 118, UR = 144, UV = 0.51), L. (FC = 111, UR = 142, UV = 0.51), L. (FC = 107, UR = 121, UV = 0.43), - L. (FC = 102; UR = 119, UV = 0.43), (L.) Obseck (FC = 97, UR = 120, UV = 0.43), Asso (FC = 92, UR = 115, UV = 0.41) and the holy water 'Zamzam' (FC = 110, UR = 110, UV = 0.43) respectively. Mixtures of two or more ingredients were frequently used. The use of Pelophylax saharicus skin' was reported for the first time for the treatment of visible tumors and skin cancer. This is the first study documenting the traditional uses of various natural products for cancer treatment in Algeria. Our findings are relevant to document the traditional uses of numerous natural products and to provide background basis to search for novel compounds for cancer therapy.
传统医学和补充医学是包括癌症在内的多种疾病的重要医疗保健来源，但其重要性往往被低估。然而，人们对北非的民族医学知识和实践知之甚少。本研究的主要目的是识别和分析阿尔及利亚民族药理学中用于癌症治疗的各种天然产物。为此，在2015年6月至2019年7月期间进行的实地研究中，在阿尔及利亚的12个地点对225名传统治疗师、草药医生和从业者进行了半结构化访谈。访谈内容包括天然产物的通俗名称和方言名称、使用和给药方式、剂量、治疗周期、毒性和副作用等数据。所得结果显示，使用了113种药用植物（属于53个科和104个属）、10种动物物种以及来自不同来源的各种产品和副产品，如蜂蜜、橄榄油、刺、尿液、牛奶、动物脂肪和渗渗圣水。根据引用频率（FC）、使用报告（UR）和使用价值（UV），用于癌症治疗的最常用天然产物分别是蜂蜜（FC = 181，UR = 194，UV = 0.65）、L.（FC = 131，UR = 152，UV = 0.54）、L.（FC = 118，UR = 144，UV = 0.51）、L.（FC = 111，UR = 142，UV = 0.51）、L.（FC = 107，UR = 121，UV = 0.43）、-L.（FC = 102；UR = 119，UV = 0.43）、(L.) Obseck（FC = 97，UR = 120，UV = 0.43）、Asso（FC = 92，UR = 115，UV = 0.41）和圣水“渗渗”（FC = 110，UR = 110，UV = 0.43）。经常使用两种或更多成分的混合物。首次报道使用撒哈拉绿蟾蜍皮治疗可见肿瘤和皮肤癌。这是第一项记录阿尔及利亚各种天然产物用于癌症治疗的传统用途的研究。我们的研究结果对于记录众多天然产物的传统用途以及为寻找用于癌症治疗的新化合物提供背景依据具有重要意义。
