Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan.
Laboratory of Biocontrol and Antimicrobial Resistance, Orel State University Named After I.S. Turgenev, 302026, Orel, Russia.
Clin Nutr. 2019 Dec;38(6):2499-2503. doi: 10.1016/j.clnu.2018.12.019. Epub 2018 Dec 27.
Globally, cancer ranks among the most common causes of death. Multiple experimental and clinical studies have investigated anticancer effects of honey with promising results. This study focused on potential background mechanisms of this effect.
The current literature was reviewed for potential anticancer pathways which are suggested for honey and its ingredients.
Flavonoids (kaempferol, catechin, and quercetin) and phenolic acids (caffeic acid and gallic acid) are the most important ingredients of honey with known anti-cancer activity. The main suggested mechanisms for anti-cancer activity of honey and its ingredients are antioxidant, apoptotic, tumor necrosis factor inhibiting, antiproliferative, immunomodulatory, anti-inflammatory and estrogenic effects.
This review collates the current scientific understanding on the mechanism of anti-cancer activity of honey.
在全球范围内，癌症是最常见的死亡原因之一。多项实验和临床研究都发现了蜂蜜具有抗癌作用，且结果十分有前景。本研究主要关注这一作用的潜在背景机制。
对现有文献进行了综述，探讨了蜂蜜及其成分具有抗癌作用的潜在途径。
黄酮类化合物（山柰酚、儿茶素和槲皮素）和酚酸（咖啡酸和没食子酸）是具有已知抗癌活性的蜂蜜的最重要成分。蜂蜜及其成分抗癌活性的主要作用机制包括抗氧化、凋亡、肿瘤坏死因子抑制、抗增殖、免疫调节、抗炎和雌激素作用。
本综述总结了目前科学界对蜂蜜抗癌活性机制的认识。
