Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Department of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Rev Bras Ginecol Obstet. 2020 Nov;42(11):705-711. doi: 10.1055/s-0040-1715140. Epub 2020 Nov 30.
To determine pregnancy outcomes in women with systemic lupus erythematosus (SLE) who were treated with hydroxychloroquine in a tertiary center.
A retrospective study involving pregnant women with SLE who had antenatal follow-up and delivery in between 1 January 2007 and 1 January 2017. All participants were retrospectively enrolled and categorized into two groups based on hydroxychloroquine treatment during pregnancy.
There were 82 pregnancies included with 47 (57.3%) in the hydroxychloroquine group and 35 (42.7%) in the non-hydroxychloroquine group. Amongst hydroxychloroquine users, there were significantly more pregnancies with musculoskeletal involvement ( = 0.03), heavier mean neonatal birthweight ( = 0.02), and prolonged duration of pregnancy ( = 0.001). In non-hydroxychloroquine patients, there were significantly more recurrent miscarriages ( = 0.003), incidence of hypertension ( = 0.01) and gestational diabetes mellitus ( = 0.01) and concurrent medical illness ( = 0.005). Hydroxychloroquine use during pregnancy was protective against hypertension ( = 0.001), and the gestational age at delivery had significant effect on the neonatal birthweight ( = 0.001). However, duration of the disease had a significant negative effect on the neonatal birthweight ( = 0.016).
Hydroxychloroquine enhanced better neonatal outcomes and reduced adverse pregnancy outcomes and antenatal complications such as hypertension and diabetes.
在一家三级中心，确定接受羟氯喹治疗的系统性红斑狼疮（SLE）女性的妊娠结局。
一项回顾性研究，纳入了 2007 年 1 月 1 日至 2017 年 1 月 1 日期间在产前检查和分娩的 SLE 孕妇。所有参与者均为回顾性入组，并根据妊娠期间是否使用羟氯喹分为两组。
共纳入 82 例妊娠，其中 47 例（57.3%）使用羟氯喹，35 例（42.7%）未使用羟氯喹。在羟氯喹使用者中，肌肉骨骼受累的妊娠明显更多（ = 0.03），新生儿平均出生体重更重（ = 0.02），妊娠时间延长（ = 0.001）。在未使用羟氯喹的患者中，复发性流产（ = 0.003）、高血压（ = 0.01）、妊娠期糖尿病（ = 0.01）和合并内科疾病（ = 0.005）的发生率明显更高。妊娠期间使用羟氯喹可预防高血压（ = 0.001），分娩时的孕龄对新生儿出生体重有显著影响（ = 0.001）。然而，疾病持续时间对新生儿出生体重有显著的负面影响（ = 0.016）。
羟氯喹改善了新生儿结局，并降低了高血压和糖尿病等不良妊娠结局和产前并发症的发生率。
