School of Pharmacy, International Medical University (IMU), Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Nanotherapeutics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia.
School of Pharmacy, International Medical University (IMU), Bukit Jalil, 57000 Kuala Lumpur, Malaysia; Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya Medical Centre, Subang Jaya, 47500 Selangor, Malaysia.
Med Hypotheses. 2020 Nov;144:110298. doi: 10.1016/j.mehy.2020.110298. Epub 2020 Sep 24.
Outbreaks of influenza infections in the past have severely impacted global health and socioeconomic growth. Antivirals and vaccines are remarkable medical innovations that have been successful in reducing the rates of morbidity and mortality from this disease. However, the relentless emergence of drug resistance has led to a worrisome increase in the trend of influenza outbreaks, characterized by worsened clinical outcomes as well as increased economic burden. This has prompted the need for breakthrough innovations that can effectively manage influenza outbreaks. This article provides an insight into a novel hypothesis that describes how the integration of nanomedicine, with the development of drugs and vaccines can potentially enhance body immune response and the efficacies of anti-viral therapeutics to combat influenza infections.
过去流感疫情的爆发严重影响了全球的健康和社会经济发展。抗病毒药物和疫苗是医学领域的重大创新,成功降低了该疾病的发病率和死亡率。然而,抗药性的不断出现导致流感疫情呈上升趋势,这不仅使临床结果恶化,还增加了经济负担。这就需要有突破性的创新来有效控制流感疫情。本文提出了一个新的假设,即纳米医学与药物和疫苗的开发相结合,如何增强人体的免疫反应,提高抗病毒治疗的疗效,从而对抗流感感染。