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先进的药物输送系统有助于针对冠状病毒病(COVID-19):一种假说。

Advanced drug delivery systems can assist in targeting coronavirus disease (COVID-19): A hypothesis.

机构信息

Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, Australia; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India.

Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India.

出版信息

Med Hypotheses. 2020 Nov;144:110254. doi: 10.1016/j.mehy.2020.110254. Epub 2020 Sep 10.

Abstract

The highly contagious coronavirus, which had already affected more than 2 million people in 210 countries, triggered a colossal economic crisis consequently resulting from measures adopted by various goverments to limit transmission. This has placed the lives of many people infected worldwide at great risk. Currently there are no established or validated treatments for COVID-19, that is approved worldwide. Nanocarriers may offer a wide range of applications that could be developed into risk-free approaches for successful therapeutic strategies that may lead to immunisation against the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) which is the primary causative organism that had led to the current COVID-19 pandemic. We address existing as well as emerging therapeutic and prophylactic approaches that may enable us to effectively combat this pandemic, and also may help to identify the key areas where nano-scientists can step in.

摘要

高度传染性的冠状病毒已经在 210 个国家感染了超过 200 万人,各国政府为限制病毒传播而采取的措施引发了巨大的经济危机。这使得全球许多感染者的生命处于巨大的危险之中。目前,还没有经过世界卫生组织批准的针对 COVID-19 的既定或经过验证的治疗方法。纳米载体可能提供广泛的应用,这些应用可以开发成无风险的方法,以成功实现治疗策略,从而可能导致对严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)的免疫,SARS-CoV-2 是导致当前 COVID-19 大流行的主要病原体。我们讨论了现有的和新兴的治疗和预防方法,这些方法可能使我们能够有效地对抗这一大流行病,并有助于确定纳米科学家可以介入的关键领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32af/7481067/243e3078f766/gr1_lrg.jpg

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