Chemistry Department, 2036 Main Mall - UBC, Vancouver, BC V6T1Z1, Canada.
Med Hypotheses. 2020 Nov;144:110280. doi: 10.1016/j.mehy.2020.110280. Epub 2020 Sep 16.
This hypothesis raises the interesting prospect that dihydroxyacetone (DHA), the key ingredient in self-tanning creams, when applied daily to the face and hands may have prophylactic action against SARS-COV-2 transmission and infection. The scientific and mechanistic basis for this hypothesis is elaborated based on our understanding of the chemical reactivity of DHA with proteins to afford advanced glycation products. This piece ends with a proposal for doing key experiments that can be run to test this hypothesis. As more than 30 million people have been infected with this disease world-wide, a safe method for stopping spread is worthy of consideration. Publication of this hypothesis would enable the scientific community at large to test this in a clinically meaningful setting to address the potential for DHA-based prophylaxis. Given the calamity of this crisis, it is anticipated that the publication of this hypothesis, which is supported by key studies on protein and nucleoside glycation, can be disseminated to as many researchers as possible.
这一假说提出了一个有趣的前景，即二羟丙酮（DHA），是美黑霜的关键成分，如果每天涂抹在面部和手部，可能对预防 SARS-CoV-2 传播和感染有作用。这一假说的科学和机制基础是基于我们对 DHA 与蛋白质发生化学反应以产生糖基化终产物的理解。本文最后提出了一些关键实验的建议，可以进行这些实验来检验这一假说。由于全世界已有超过 3000 万人感染了这种疾病，因此寻找一种安全的方法来阻止其传播是值得考虑的。这一假说的发表将使广大科学界能够在临床上有意义的环境中对此进行测试，以探讨基于 DHA 的预防措施的潜力。鉴于这场危机的严重性，预计这一假说的发表，以及对蛋白质和核苷糖基化的关键研究的支持，能够传播给尽可能多的研究人员。
