Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Environ Pollut. 2020 Dec;267:115647. doi: 10.1016/j.envpol.2020.115647. Epub 2020 Sep 18.
Copper have been reported to be associated with metabolic diseases. However, results on copper exposure with blood lipid profiles are inconsistent, and the underlying mechanisms of this association remain unclear. This study focused on investigating associations between urinary copper and blood lipid profiles; and exploring the potential role of systemic inflammation in such relationships. Concentrations of urinary copper, plasma C-reactive protein (CRP), and four blood lipid parameters (e.g., Total cholesterol [TC], triglycerides [TG], low-density lipoprotein cholesterol [LDL-C], and high-density lipoprotein cholesterol [HDL-C]) were measured in the adult participants from Wuhan-Zhuhai cohort. The associations between copper, CRP, and four blood lipids were assessed by the multivariable linear regression models, and the 3D mesh graphs was used to examine the joint effects of copper exposure and CRP on four blood lipid parameters. In addition, we used mediation analysis to investigate the mediated effects of CRP in the relationships between copper exposure and blood lipid profiles. Each 1% increase in urinary copper was statistically significantly associated with a 5.32% (95% CI: 2.48%, 8.24%) increase in TG after adjusting for the confounders (P < 0.05). No significant associations were observed between urinary copper and the other three blood lipid parameters (all P > 0.05). In addition, urinary copper increased monotonically with plasma CRP elevation, which in turn, was positively associated with TC, TG, and LDL-C and negatively related to HDL-C (all P < 0.05). Results from 3D mesh graphs demonstrated that increased levels of plasma CRP with higher urinary copper corresponded to higher TC, TG, LDL-C, and lower HDL-C concentrations. Mediation analysis observed that CRP mediated 6.27% in the relationships of urinary copper and TG. These findings suggest that systemic inflammation partly mediated the association between copper exposure and abnormal blood lipid, and may contribute to the development of dyslipidemias.
铜已被报道与代谢性疾病有关。然而，关于铜暴露与血脂谱之间的关系的结果并不一致，其潜在的关联机制尚不清楚。本研究主要集中在研究尿铜与血脂谱之间的关系；并探讨全身炎症在这种关系中的潜在作用。在武汉-珠海队列的成年参与者中测量了尿铜、血浆 C 反应蛋白 (CRP) 和四个血脂参数（如总胆固醇 [TC]、甘油三酯 [TG]、低密度脂蛋白胆固醇 [LDL-C] 和高密度脂蛋白胆固醇 [HDL-C]）的浓度。使用多变量线性回归模型评估铜、CRP 和四个血脂之间的关联，并使用 3D 网格图检查铜暴露和 CRP 对四个血脂参数的联合影响。此外，我们使用中介分析来研究 CRP 在铜暴露与血脂谱之间的关系中的中介作用。在调整混杂因素后，尿铜每增加 1%，与 TG 增加 5.32%（95%CI：2.48%，8.24%）具有统计学意义（P<0.05）。尿铜与其他三个血脂参数之间没有显著相关性（均 P>0.05）。此外，尿铜与血浆 CRP 升高呈单调递增关系，而 CRP 则与 TC、TG 和 LDL-C 呈正相关，与 HDL-C 呈负相关（均 P<0.05）。3D 网格图的结果表明，随着血浆 CRP 水平的升高，尿铜水平升高对应于 TC、TG、LDL-C 浓度升高和 HDL-C 浓度降低。中介分析观察到 CRP 介导了尿铜与 TG 关系的 6.27%。这些发现表明，全身炎症部分介导了铜暴露与异常血脂之间的关联，并可能导致血脂异常的发生。
