Department of Cognitive Neuroscience, Neurosciences Division, Institute of Cellular Physiology, National Autonomous University of Mexico, UNAM, Mexico City 04510, Mexico.
Department of Molecular Biology and Histocompatibility, "Dr. Manuel Gea González" General Hospital, Mexico City 14080, Mexico.
Int J Mol Sci. 2020 Nov 24;21(23):8882. doi: 10.3390/ijms21238882.
The Transient Receptor Vanilloid 1 (TRPV1) or capsaicin receptor is a nonselective cation channel, which is abundantly expressed in nociceptors. This channel is an important transducer of several noxious stimuli, having a pivotal role in pain development. Several TRPV1 studies have focused on understanding its structure and function, as well as on the identification of compounds that regulate its activity. The intracellular roles of these channels have also been explored, highlighting TRPV1's actions in the homeostasis of Ca in organelles such as the mitochondria. These studies have evidenced how the activation of TRPV1 affects mitochondrial functions and how this organelle can regulate TRPV1-mediated nociception. The close relationship between this channel and mitochondria has been determined in neuronal and non-neuronal cells, demonstrating that TRPV1 activation strongly impacts on cell physiology. This review focuses on describing experimental evidence showing that TRPV1 influences mitochondrial function.
瞬时受体香草酸 1（TRPV1）或辣椒素受体是一种非选择性阳离子通道，在伤害感受器中大量表达。该通道是多种有害刺激的重要转导器，在疼痛发展中起着关键作用。多项 TRPV1 研究集中在理解其结构和功能，以及鉴定调节其活性的化合物上。这些通道的细胞内作用也得到了探索，强调了 TRPV1 在细胞器（如线粒体）中钙稳态中的作用。这些研究表明 TRPV1 的激活如何影响线粒体功能，以及该细胞器如何调节 TRPV1 介导的伤害感受。在神经元和非神经元细胞中已经确定了该通道和线粒体之间的密切关系，证明 TRPV1 的激活强烈影响细胞生理学。本综述重点描述了实验证据，表明 TRPV1 影响线粒体功能。
