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辣椒素局部应用对大鼠模型的心脏保护和降压作用

Cardioprotective and Antihypertensive Effects of Topical Capsaicin in a Rat Model.

作者信息

Torres-Narváez Juan Carlos, Castrejón-Téllez Vicente, Sánchez-Aguilar María, Cano-Martínez Agustina, Soria-Castro Elizabeth, Díaz-Juárez Julieta Anabell, Pérez-Torres Israel, Guarner-Lans Verónica, Varela-López Elvira, Ibarra-Lara María de la Luz, Zarco-Olvera Gabriela, Vargas-González Alvaro, Flores-Chávez Pedro L, Del Valle-Mondragón Leonardo

机构信息

Departamento de Farmacología Dr. Rafael Méndez Martínez, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Ciudad de México 14080, Mexico.

Departamento de Fisiología, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, Ciudad de México 14080, Mexico.

出版信息

Antioxidants (Basel). 2025 Aug 6;14(8):966. doi: 10.3390/antiox14080966.

DOI:10.3390/antiox14080966
PMID:40867862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12383131/
Abstract

TRPV1 regulates neuronal and vascular function mediated by NO and CGRP. Systemic arterial hypertension (SAH) induces an imbalance in vascular mediators NO and CGRP by altering the transport of Ca ions through TRPV1, generating cellular damage. We studied the effect of topical capsaicin (CS) treatment on cardiac mechanical work, oxidative stress (TAC, NO, BH4, and BH2), cellular damage (MDA, MTO, and 8HO2dG), and inflammation (IL-6 and TNFα), generated by SAH, which was induced by -NAME, in male Wistar rats. CS was added to a moisturizing cream and applied to the abdomen of animals for two weeks. Experimental groups were as follows: (1) Control, (2) Control+Cream, (3) Hypertensive, and (4) Hypertensive+Cream. Hearts were exposed to ischemia-reperfusion (I-R) using the Langendorff technique to study the potential cardioprotection of CS. Expression of SOD1, SOD2, catalase, eNOS, pNOS, TRPV1, and CGRP in cardiac tissue was evaluated. In the Hypertensive group, TRPV1 activation by CS (Hypertensive+Cream) reduced oxidative stress (OS), decreasing cellular damage and inflammation and increasing TAC, modulating biochemical and tissue alterations induced by OS generated by SAH. In parallel, an increase in tissue levels and the expression of CGRP, TRPV1, and eNOS, induced by CS, was observed. These findings indicate that pretreatment with CS attenuates cardiac I-R and SAH injury in rats. The cardioprotective mechanism may be based on TRPV1-mediated CGRP overexpression.

摘要

瞬时受体电位香草酸亚型1（TRPV1）调节由一氧化氮（NO）和降钙素基因相关肽（CGRP）介导的神经元和血管功能。系统性动脉高血压（SAH）通过改变钙离子经TRPV1的转运，导致血管介质NO和CGRP失衡，进而造成细胞损伤。我们研究了局部应用辣椒素（CS）对由-NAME诱导的SAH所产生的心脏机械功、氧化应激（总抗氧化能力、NO、四氢生物蝶呤和二氢生物蝶呤）、细胞损伤（丙二醛、甲硫氨酸亚砜还原酶和8-羟基脱氧鸟苷）以及炎症（白细胞介素-6和肿瘤坏死因子α）的影响，实验对象为雄性Wistar大鼠。将CS添加到保湿霜中，涂抹于动物腹部，持续两周。实验组如下：（1）对照组，（2）对照组+霜剂组，（3）高血压组，（4）高血压+霜剂组。采用Langendorff技术使心脏暴露于缺血-再灌注（I-R）状态，以研究CS的潜在心脏保护作用。评估了心脏组织中超氧化物歧化酶1（SOD1）、超氧化物歧化酶2（SOD2）、过氧化氢酶、内皮型一氧化氮合酶（eNOS）、磷酸化内皮型一氧化氮合酶（pNOS）、TRPV1和CGRP的表达。在高血压组中，CS激活TRPV1（高血压+霜剂组）可减轻氧化应激（OS），减少细胞损伤和炎症，并增加总抗氧化能力，调节由SAH产生的OS所诱导的生化和组织改变。同时，观察到CS诱导组织中CGRP、TRPV1和eNOS水平及表达增加。这些发现表明，CS预处理可减轻大鼠心脏I-R损伤和SAH损伤。心脏保护机制可能基于TRPV1介导的CGRP过表达。

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