Okazawa Hidehiko, Ikawa Masamichi, Tsujikawa Tetsuya, Makino Akira, Mori Tetsuya, Kiyono Yasushi, Kosaka Hirotaka
Biomedical Imaging Research Center, University of Fukui, Eiheiji-cho 910-1193, Japan.
Department of Advanced Medicine for Community Healthcare, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Diagnostics (Basel). 2020 Nov 24;10(12):993. doi: 10.3390/diagnostics10120993.
A noninvasive image-derived input function (IDIF) method using PET/MRI was applied to quantitative measurements of [C] Pittsburgh compound-B (PiB) distribution volume (DV) and compared with other metrics. Fifty-three patients suspected of early dementia (71 ± 11 y) underwent 70 min [C]PiB PET/MRI. Nineteen of them (68 ± 11 y) without head motion during the scan were enrolled in this study and compared with 16 age-matched healthy controls (CTL: 68 ± 11 y). The dynamic frames reconstructed from listmode PET data were used for DV calculation. IDIF with metabolite correction was applied to the Logan plot method, and DV was normalized into DV ratio (DVR) images using the cerebellar reference (DVR). DVR and standardized uptake value ratio (SUVR) images were also calculated using the reference tissue graphical method (DVR) and the 50-70 min static data with cerebellar reference, respectively. Cortical values were compared using the 3D-T1WI MRI segmentation. All patients were assigned to the early Alzheimer's disease (eAD) group because of positive [C]PiB accumulation. The correlations of regional values were better for DVR vs. DVR (r = 0.97) than for SUVR vs. DVR (r = 0.88). However, all metrics clearly differentiated eAD from CTL with appropriate thresholds. Noninvasive quantitative [C]PiB PET/MRI measurement provided equivalent DVRs with the two methods. SUVR images showed acceptable results despite inferior variability and image quality to DVR images.
一种使用正电子发射断层扫描/磁共振成像（PET/MRI）的非侵入性图像衍生输入函数（IDIF）方法被应用于定量测量[C]匹兹堡化合物B（PiB）分布容积（DV），并与其他指标进行比较。五十三名疑似早期痴呆的患者（71±11岁）接受了70分钟的[C]PiB PET/MRI检查。其中19名在扫描过程中无头部运动的患者（68±11岁）被纳入本研究，并与16名年龄匹配的健康对照者（CTL：68±11岁）进行比较。从列表模式PET数据重建的动态帧用于DV计算。将带有代谢物校正的IDIF应用于洛根图法，并使用小脑参考（DVR）将DV标准化为DV比值（DVR）图像。还分别使用参考组织图形法（DVR）和带有小脑参考的50 - 70分钟静态数据计算DVR和标准化摄取值比值（SUVR）图像。使用三维T1加权磁共振成像（3D-T1WI MRI）分割比较皮质值。由于[C]PiB积累呈阳性，所有患者均被分配到早期阿尔茨海默病（eAD）组。DVR与DVR之间的区域值相关性（r = 0.97）优于SUVR与DVR之间的相关性（r = 0.88）。然而，所有指标通过适当的阈值都能清晰地区分eAD和CTL。非侵入性定量[C]PiB PET/MRI测量用两种方法提供了等效的DVR。尽管SUVR图像的变异性和图像质量不如DVR图像，但显示出可接受的结果。
