抗生素磺胺嘧啶对土壤细菌群落生长的毒性可能随时间推移而增强。
The Toxicity Exerted by the Antibiotic Sulfadiazine on the Growth of Soil Bacterial Communities May Increase over Time.
机构信息
Área de Edafoloxía e Química Agrícola, Facultade de Ciencias, Universidade de Vigo, 32004 Ourense, Galiza, Spain.
CITACA-Clúster de Investigación e Transferencia Agroalimentaria do Campus Auga, Universidade de Vigo, 32004 Ourense, Galiza, Spain.
出版信息
Int J Environ Res Public Health. 2020 Nov 26;17(23):8773. doi: 10.3390/ijerph17238773.
The toxicity exerted by the antibiotic sulfadiazine on the growth of soil bacterial communities was studied in two agricultural soils for a period of 100 days. In the short-term (2 days of incubation), the effect of sulfadiazine on bacterial growth was low (no inhibition or inhibition <32% for a dose of 2000 mg·kg). However, sulfadiazine toxicity increased with time, achieving values of 40% inhibition, affecting bacterial growth in both soils after 100 days of incubation. These results, which were here observed for the first time for any antibiotic in soil samples, suggest that long-term experiments would be required for performing an adequate antibiotics risk assessment, as short-term experiments may underestimate toxicity effects.
研究了抗生素磺胺嘧啶对两种农业土壤中土壤细菌群落生长的毒性作用，为期 100 天。在短期（2 天的孵育期），磺胺嘧啶对细菌生长的影响较低（剂量为 2000 毫克/千克时，无抑制或抑制<32%）。然而，磺胺嘧啶的毒性随时间而增加，在孵育 100 天后达到 40%的抑制率，影响了两种土壤中细菌的生长。这些结果是首次在土壤样本中观察到的任何抗生素的结果，表明需要进行长期实验来进行充分的抗生素风险评估，因为短期实验可能低估毒性效应。
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