School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India.
Research Center for Chromatography and Mass Spectrometry, CROM-MASS, CIBIMOL-CENIVAM, Industrial University of Santander, Carrera 27, Calle 9, Edificio 45, Bucaramanga 680002, Colombia.
Molecules. 2020 Nov 26;25(23):5555. doi: 10.3390/molecules25235555.
(Saxifragaceae) genus is native to central Asia and encompasses 32 known species. Among these, nine are of pharmacological relevance. In the Indian system of traditional medicine (Ayurveda), "Pashanabheda" (stone breaker) is an elite drug formulation obtained from the rhizomes of . species also possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic. This review provides explicit information on the traditional uses, phytochemistry, and pharmacological significance of the genus . The extant literature concerned was systematically collected from various databases, weblinks, blogs, books, and theses to select 174 references for detailed analysis. To date, 152 chemical constituents have been identified and characterized from the genus that belong to the chemical classes of polyphenols, phenolic-glycosides, lactones, quinones, sterols, tannins, terpenes, and others. alone possesses 104 bioactive compounds. Meticulous pharmacological and phytochemical studies on species and its conservation could yield more reliable compounds and products of pharmacological significance for better healthcare.
(Saxifragaceae) 属原产于中亚，包含 32 种已知物种。其中，有 9 种具有药理学意义。在印度传统医学（阿育吠陀）体系中，“Pashanabheda”（结石破碎机）是一种从 种的根茎中提取的优质药物制剂。该 种还具有其他几种生物活性，如利尿、抗糖尿病、镇咳、杀虫、抗炎、退热、抗缓激肽、抗病毒、抗菌、抗疟、保肝、抗溃疡、抗癌、抗氧化、抗肥胖和适应原性。
本综述提供了关于该属的传统用途、植物化学和药理学意义的明确信息。为了进行详细分析，从各种数据库、网络链接、博客、书籍和论文中系统地收集了与现有文献相关的信息，共选择了 174 篇参考文献。迄今为止，已经从该属中鉴定和表征了 152 种化学成分，它们属于多酚、酚糖苷、内酯、醌、甾醇、单宁、萜类和其他化学类别的化合物。 种独自拥有 104 种具有生物活性的化合物。对 种及其保护进行细致的药理学和植物化学研究，可能会产生更可靠的化合物和具有药理意义的产品，以促进更好的医疗保健。
