Deknudt G, Léonard A, Arany J, Jenar-Du Buisson G, Delavignette E
Biology Department, S.C.K.-C.E.N., Brussels, Belgium.
Mutagenesis. 1986 Jan;1(1):33-4. doi: 10.1093/mutage/1.1.33.
The ability of sodium meta-arsenite (NaAsO2) to produce genetic damage in vivo has been evaluated in mice by the micronucleus test on bone marrow cells and the dominant lethality and sperm abnormality assays on male germ cells. The dose-related linear increase of micronuclei observed in somatic cells together with the negative results obtained in reproductive cells suggest that NaAsO2, under the conditions of the present experiments, displays clastogenic properties in vivo in laboratory animals, but is unable to produce heritable damage.
通过对小鼠骨髓细胞进行微核试验以及对雄性生殖细胞进行显性致死和精子异常试验，评估了偏亚砷酸钠（NaAsO₂）在体内产生遗传损伤的能力。在体细胞中观察到的微核数量与剂量相关的线性增加，以及在生殖细胞中获得的阴性结果表明，在本实验条件下，NaAsO₂ 在实验动物体内具有致断裂特性，但无法产生可遗传的损伤。
