Pashin Iu V, Kozachenko V I, Toroptsev S N
Genetika. 1984 Feb;20(2):365-6.
After single i. p. injection of arsenic trioxide, at the dosage range of 1/4 to 1/40 LD50 into hybrid mice (CBA X C57B1/6J)F1, no induction of dominant lethals in male germ cells was observed. However, it led to an increase in the number of micronuclei in the erythrocytes of bone marrow. Treatment with the effective dose of thioTEPA, causing an increase in the number of dominant lethals in male germ cells and in the number of micronuclei in the erythrocytes of bone marrow, followed by injection of arsenic trioxide, resulted in inhibition of the mutagenic activity of thioTEPA. This inhibition increased proportionally with the dose of arsenic trioxide.
对杂交小鼠（CBA×C57B1/6J）F1单次腹腔注射三氧化二砷，剂量范围为1/4至1/40 LD50，未观察到雄性生殖细胞中显性致死突变的诱导。然而，它导致骨髓红细胞中微核数量增加。用有效剂量的噻替派处理，导致雄性生殖细胞中显性致死突变数量和骨髓红细胞中微核数量增加，随后注射三氧化二砷，结果抑制了噻替派的诱变活性。这种抑制作用与三氧化二砷的剂量成比例增加。
