Shoemaker L, Welch T R, Bergstrom W, Abrams S A, Yergey A L, Vieira N
Department of Pediatrics, University of Cincinnati College of Medicine, Ohio 45229.
Pediatr Res. 1993 Jan;33(1):92-6. doi: 10.1203/00006450-199301000-00019.
Metabolic investigations, including the use of stable isotopes of calcium, were used to study calcium kinetics in three children with the hyperprostaglandin E syndrome. The studies were performed both during indomethacin treatment and in the absence of therapy. Off therapy, each child had hypercalciuria (mean urinary calcium excretion 0.478 mM/kg/d), hyperprostaglandinuria, and elevated serum calcitriol concentration. All had diminished bone density and were euparathyroid. Indomethacin treatment was associated with a marked reduction in serum calcitriol concentration, as well as decreased prostaglandin E excretion. Mean urinary calcium excretion fell to 0.135 mM/kg/d. The stable isotope studies defined two components to the hypercalciuria of this disease: an indomethacin-sensitive dietary contribution and a relatively indomethacin-resistant bone resorptive element. Bone densitometry confirmed the presence of the resorptive element by demonstrating skeletal demineralization.
采用包括使用钙的稳定同位素在内的代谢研究方法，对三名患有高前列腺素E综合征的儿童的钙动力学进行了研究。这些研究在吲哚美辛治疗期间和未进行治疗时均进行。在未治疗时，每个儿童均有高钙尿症（平均尿钙排泄量为0.478 mM/kg/天）、高前列腺素尿症和血清骨化三醇浓度升高。所有儿童的骨密度均降低且甲状旁腺功能正常。吲哚美辛治疗与血清骨化三醇浓度显著降低以及前列腺素E排泄减少有关。平均尿钙排泄量降至0.135 mM/kg/天。稳定同位素研究确定了该疾病高钙尿症的两个组成部分：对吲哚美辛敏感的饮食因素和相对对吲哚美辛耐药的骨吸收因素。骨密度测定通过显示骨骼脱矿质证实了骨吸收因素的存在。
